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Impact of light therapy on rotating night shift workers: the EuRhythDia study
AIMS: Disturbances in circadian rhythms may promote cardiometabolic disorders in rotating night shift workers (r-NSWs). We hypothesized that timed light therapy might reverse disrupted circadian rhythms and glucose intolerance observed among r-NSWs). METHODS: R-NSWs were randomly assigned to a proto...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430001/ https://www.ncbi.nlm.nih.gov/pubmed/36044097 http://dx.doi.org/10.1007/s00592-022-01956-2 |
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author | Rizza, Stefano Luzi, Alessio Mavilio, Maria Ballanti, Marta Massimi, Arianna Porzio, Ottavia Magrini, Andrea Hannemann, Juliane Menghini, Rossella Cridland, Jonathan Staels, Bart Grant, Peter J. Boger, Rainer H. Marx, Nikolaus Federici, Massimo |
author_facet | Rizza, Stefano Luzi, Alessio Mavilio, Maria Ballanti, Marta Massimi, Arianna Porzio, Ottavia Magrini, Andrea Hannemann, Juliane Menghini, Rossella Cridland, Jonathan Staels, Bart Grant, Peter J. Boger, Rainer H. Marx, Nikolaus Federici, Massimo |
author_sort | Rizza, Stefano |
collection | PubMed |
description | AIMS: Disturbances in circadian rhythms may promote cardiometabolic disorders in rotating night shift workers (r-NSWs). We hypothesized that timed light therapy might reverse disrupted circadian rhythms and glucose intolerance observed among r-NSWs). METHODS: R-NSWs were randomly assigned to a protocol that included 12 weeks on followed by 12 weeks off light therapy (n = 13; 6 men; mean age, 39.5 ± 7.3 years) or a no-treatment control group (n = 9; 3 men; mean age 41.7 ± 6.3 years). Experimental and control participants underwent identical metabolic evaluations that included anthropometric, metabolic (including oral glucose tolerance tests), lipid, and inflammation-associated parameters together with an assessment of sleep quality and expression of circadian transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs) at baseline, 12 weeks, and 24 weeks of the protocol. RESULTS: Twelve weeks of warm white-light exposure (10,000 lx at 35 cm for 30 min per day) had no impact on sleep, metabolic, or inflammation-associated parameters among r-NSWs in the experimental group. However, our findings revealed significant decreases in REV-ERBα gene expression (p = 0.048) and increases in the REV-ERBα/BMAL1 ratio (p = 0.040) compared to baseline in PBMCs isolated from this cohort. Diminished expression of REV-ERBα persisted, although the REV-ERBα/BMAL1 ratio returned to baseline levels after the subsequent 12-day wash-out period. CONCLUSIONS: Our results revealed that intermittent light therapy had no impact on inflammatory parameters or glucose tolerance in a defined cohort of r-NSWs. However, significant changes in the expression of circadian clock genes were detected in PBMCs of these subjects undergoing light therapy. |
format | Online Article Text |
id | pubmed-9430001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-94300012022-09-01 Impact of light therapy on rotating night shift workers: the EuRhythDia study Rizza, Stefano Luzi, Alessio Mavilio, Maria Ballanti, Marta Massimi, Arianna Porzio, Ottavia Magrini, Andrea Hannemann, Juliane Menghini, Rossella Cridland, Jonathan Staels, Bart Grant, Peter J. Boger, Rainer H. Marx, Nikolaus Federici, Massimo Acta Diabetol Original Article AIMS: Disturbances in circadian rhythms may promote cardiometabolic disorders in rotating night shift workers (r-NSWs). We hypothesized that timed light therapy might reverse disrupted circadian rhythms and glucose intolerance observed among r-NSWs). METHODS: R-NSWs were randomly assigned to a protocol that included 12 weeks on followed by 12 weeks off light therapy (n = 13; 6 men; mean age, 39.5 ± 7.3 years) or a no-treatment control group (n = 9; 3 men; mean age 41.7 ± 6.3 years). Experimental and control participants underwent identical metabolic evaluations that included anthropometric, metabolic (including oral glucose tolerance tests), lipid, and inflammation-associated parameters together with an assessment of sleep quality and expression of circadian transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs) at baseline, 12 weeks, and 24 weeks of the protocol. RESULTS: Twelve weeks of warm white-light exposure (10,000 lx at 35 cm for 30 min per day) had no impact on sleep, metabolic, or inflammation-associated parameters among r-NSWs in the experimental group. However, our findings revealed significant decreases in REV-ERBα gene expression (p = 0.048) and increases in the REV-ERBα/BMAL1 ratio (p = 0.040) compared to baseline in PBMCs isolated from this cohort. Diminished expression of REV-ERBα persisted, although the REV-ERBα/BMAL1 ratio returned to baseline levels after the subsequent 12-day wash-out period. CONCLUSIONS: Our results revealed that intermittent light therapy had no impact on inflammatory parameters or glucose tolerance in a defined cohort of r-NSWs. However, significant changes in the expression of circadian clock genes were detected in PBMCs of these subjects undergoing light therapy. Springer Milan 2022-08-31 2022 /pmc/articles/PMC9430001/ /pubmed/36044097 http://dx.doi.org/10.1007/s00592-022-01956-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Rizza, Stefano Luzi, Alessio Mavilio, Maria Ballanti, Marta Massimi, Arianna Porzio, Ottavia Magrini, Andrea Hannemann, Juliane Menghini, Rossella Cridland, Jonathan Staels, Bart Grant, Peter J. Boger, Rainer H. Marx, Nikolaus Federici, Massimo Impact of light therapy on rotating night shift workers: the EuRhythDia study |
title | Impact of light therapy on rotating night shift workers: the EuRhythDia study |
title_full | Impact of light therapy on rotating night shift workers: the EuRhythDia study |
title_fullStr | Impact of light therapy on rotating night shift workers: the EuRhythDia study |
title_full_unstemmed | Impact of light therapy on rotating night shift workers: the EuRhythDia study |
title_short | Impact of light therapy on rotating night shift workers: the EuRhythDia study |
title_sort | impact of light therapy on rotating night shift workers: the eurhythdia study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430001/ https://www.ncbi.nlm.nih.gov/pubmed/36044097 http://dx.doi.org/10.1007/s00592-022-01956-2 |
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