Attenuated Viral Replication of Avian Infectious Bronchitis Virus with a Novel 82-Nucleotide Deletion in the 5a Gene Indicates a Critical Role for 5a in Virus-Host Interactions

We previously found that a deletion in γ-coronavirus Infectious bronchitis virus (IBV) accessory gene 5a is critical for decreased viral pathogenicity in chickens. Here, we systematically analyzed IBV virus infection: invasion, genome replication, subgenomic mRNA (sgmRNA) synthesis, protein synthesi...

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Detalles Bibliográficos
Autores principales: Zhao, Ye, Liang, Rong, Cheng, Jinlong, Zhao, Jing, Xue, Jia, Zhang, Guozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430126/
https://www.ncbi.nlm.nih.gov/pubmed/35766501
http://dx.doi.org/10.1128/spectrum.01405-22

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