Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda

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Based on its predicted ability to affect transmissibility and pathogenesis, surveillance studies have highlighted the role of a specific mutation (P681R) in the S1/S2 furin cleavage site of the SARS-CoV-2 spike protein. Here we analyzed A.23.1, first identified in Uganda, as a P681R-containing virus...

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Detalles Bibliográficos
Autores principales: Lubinski, Bailey, Frazier, Laura E., Phan, My V. T., Bugembe, Daniel L., Cunningham, Jessie L., Tang, Tiffany, Daniel, Susan, Cotten, Matthew, Jaimes, Javier A., Whittaker, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9430374/
https://www.ncbi.nlm.nih.gov/pubmed/35766497
http://dx.doi.org/10.1128/spectrum.01514-22

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