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Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein during Coreceptor Switch with CCR5 Antagonist Therapy

HIV-1 uses CD4 as a receptor and chemokine receptors CCR5 and/or CXCR4 as coreceptors. CCR5 antagonists are a class of antiretrovirals used to inhibit viral entry. Phenotypic prediction algorithms such as Geno2Pheno are used to assess CCR5 antagonist eligibility, for which the V3 region is screened....

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Detalles Bibliográficos
Autores principales:	Du, Yueqi, Wu, Ellen, Gao, Xiang, Zhang, Jie, Martin, John C., Rosa, Bruce A., Mitreva, Makedonka, Ratner, Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431240/ https://www.ncbi.nlm.nih.gov/pubmed/35727047 http://dx.doi.org/10.1128/spectrum.00725-22

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