A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis

The ribosomal protein S6 kinase 1 (S6K1) is a relevant effector downstream of the mammalian target of rapamycin complex 1 (mTORC1), best known for its role in the control of lipid homeostasis. Consistent with this, mice lacking the S6k1 gene have a defect in their ability to induce the commitment of...

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Detalles Bibliográficos
Autores principales: Lluch, Aina, Veiga, Sonia R., Latorre, Jèssica, Moreno-Navarrete, José M., Bonifaci, Núria, Dien Nguyen, Van, Zhou, You, Höring, Marcus, Liebisch, Gerhard, Olkkonen, Vesa M., Llobet-Navas, David, Thomas, George, Rodríguez-Barrueco, Ruth, Fernández-Real, José M., Kozma, Sara C., Ortega, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431684/
https://www.ncbi.nlm.nih.gov/pubmed/35737463
http://dx.doi.org/10.1172/jci.insight.150461

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