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Non-invasive biomarkers of eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is an emerging allergen-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic inflammation. EoE diagnosis requires 15 eosinophils per high power field (eos/HPF) in tissue biopsies endoscopically obtained. The need for several endoscopies...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431887/ https://www.ncbi.nlm.nih.gov/pubmed/34842593 http://dx.doi.org/10.23750/abm.v92iS7.12401 |
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author | Votto, Martina De Filippo, Maria Castagnoli, Riccardo Delle Cave, Francesco Giffoni, Francesca Santi, Viola Vergani, Marta Caffarelli, Carlo De Amici, Mara Marseglia, Gian Luigi Licari, Amelia |
author_facet | Votto, Martina De Filippo, Maria Castagnoli, Riccardo Delle Cave, Francesco Giffoni, Francesca Santi, Viola Vergani, Marta Caffarelli, Carlo De Amici, Mara Marseglia, Gian Luigi Licari, Amelia |
author_sort | Votto, Martina |
collection | PubMed |
description | Eosinophilic esophagitis (EoE) is an emerging allergen-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic inflammation. EoE diagnosis requires 15 eosinophils per high power field (eos/HPF) in tissue biopsies endoscopically obtained. The need for several endoscopies to monitoring the disease and the absence of validated non-invasive biomarkers or tools are the main reasons for the significant burden on affected patients and the healthcare system. There is a critical need for non-invasive or minimally invasive biomarkers. In the last years, several efforts have been made to identify potential biomarkers for diagnosing and monitoring the disease that we summarized in this review. The future of EoE is exciting from both a diagnostic and therapeutic standpoint. Further research is required to confirm pheno-types and histological or serological biomarkers to provide a novel endotype classification based on different cytokine or genetic signatures relevant to precision medicine. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-9431887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-94318872022-09-15 Non-invasive biomarkers of eosinophilic esophagitis Votto, Martina De Filippo, Maria Castagnoli, Riccardo Delle Cave, Francesco Giffoni, Francesca Santi, Viola Vergani, Marta Caffarelli, Carlo De Amici, Mara Marseglia, Gian Luigi Licari, Amelia Acta Biomed Review Eosinophilic esophagitis (EoE) is an emerging allergen-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic inflammation. EoE diagnosis requires 15 eosinophils per high power field (eos/HPF) in tissue biopsies endoscopically obtained. The need for several endoscopies to monitoring the disease and the absence of validated non-invasive biomarkers or tools are the main reasons for the significant burden on affected patients and the healthcare system. There is a critical need for non-invasive or minimally invasive biomarkers. In the last years, several efforts have been made to identify potential biomarkers for diagnosing and monitoring the disease that we summarized in this review. The future of EoE is exciting from both a diagnostic and therapeutic standpoint. Further research is required to confirm pheno-types and histological or serological biomarkers to provide a novel endotype classification based on different cytokine or genetic signatures relevant to precision medicine. (www.actabiomedica.it) Mattioli 1885 2021 2021-11-29 /pmc/articles/PMC9431887/ /pubmed/34842593 http://dx.doi.org/10.23750/abm.v92iS7.12401 Text en Copyright: © 2021 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Review Votto, Martina De Filippo, Maria Castagnoli, Riccardo Delle Cave, Francesco Giffoni, Francesca Santi, Viola Vergani, Marta Caffarelli, Carlo De Amici, Mara Marseglia, Gian Luigi Licari, Amelia Non-invasive biomarkers of eosinophilic esophagitis |
title | Non-invasive biomarkers of eosinophilic esophagitis |
title_full | Non-invasive biomarkers of eosinophilic esophagitis |
title_fullStr | Non-invasive biomarkers of eosinophilic esophagitis |
title_full_unstemmed | Non-invasive biomarkers of eosinophilic esophagitis |
title_short | Non-invasive biomarkers of eosinophilic esophagitis |
title_sort | non-invasive biomarkers of eosinophilic esophagitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431887/ https://www.ncbi.nlm.nih.gov/pubmed/34842593 http://dx.doi.org/10.23750/abm.v92iS7.12401 |
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