알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상

Accumulating evidence suggests that Alzheimer's disease (AD) is not only caused by accumulation of abnormal proteins, including amyloid and tau, but is also closely associated with abnormalities in the microvascular environment including the blood-brain barrier (BBB), both of which lead to neur...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2020
Materias:
Imaging Diagnosis and Interventional Procedure in Brain and Head Neck Radiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431923/
https://www.ncbi.nlm.nih.gov/pubmed/36238621
http://dx.doi.org/10.3348/jksr.2020.81.3.488
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description Accumulating evidence suggests that Alzheimer's disease (AD) is not only caused by accumulation of abnormal proteins, including amyloid and tau, but is also closely associated with abnormalities in the microvascular environment including the blood-brain barrier (BBB), both of which lead to neuroinflammation and neurodegeneration. Application of in vivo magnetic resonance imaging (MRI) has recently increased to assess BBB permeability in AD and related diseases. Here, we provide a narrative review of BBB permeability-related pathology in Alzheimer dementia and recent MRI research on BBB permeability changes in AD and related diseases. Furthermore, we briefly introduce the measurement of BBB permeability using MRI and its methodological issues.
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spelling pubmed-94319232022-10-12 알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상 Taehan Yongsang Uihakhoe Chi Imaging Diagnosis and Interventional Procedure in Brain and Head Neck Radiology Accumulating evidence suggests that Alzheimer's disease (AD) is not only caused by accumulation of abnormal proteins, including amyloid and tau, but is also closely associated with abnormalities in the microvascular environment including the blood-brain barrier (BBB), both of which lead to neuroinflammation and neurodegeneration. Application of in vivo magnetic resonance imaging (MRI) has recently increased to assess BBB permeability in AD and related diseases. Here, we provide a narrative review of BBB permeability-related pathology in Alzheimer dementia and recent MRI research on BBB permeability changes in AD and related diseases. Furthermore, we briefly introduce the measurement of BBB permeability using MRI and its methodological issues. The Korean Society of Radiology 2020-05 2020-05-29 /pmc/articles/PMC9431923/ /pubmed/36238621 http://dx.doi.org/10.3348/jksr.2020.81.3.488 Text en Copyrights © 2020 The Korean Society of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Imaging Diagnosis and Interventional Procedure in Brain and Head Neck Radiology
알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상
title 알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상
title_full 알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상
title_fullStr 알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상
title_full_unstemmed 알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상
title_short 알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상
title_sort 알츠하이머 치매와 미세뇌혈관병리: 혈액뇌장벽 투과도 영상
topic Imaging Diagnosis and Interventional Procedure in Brain and Head Neck Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9431923/
https://www.ncbi.nlm.nih.gov/pubmed/36238621
http://dx.doi.org/10.3348/jksr.2020.81.3.488
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