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Rhinoviruses as critical agents in severe bronchiolitis in infants

OBJECTIVES: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. METHOD: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in th...

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Autores principales: Bastos, Juliana Cristina Santiago, Simas, Paulo Vitor Marques, Caserta, Leonardo Cardia, Bragunde, Alfonso Eduardo Alvarez, Marson, Fernando Augusto de Lima, Martini, Matheus Cavalheiro, Padilla, Marina Aiello, Ribeiro, José Dirceu, Santos, Márcia Mercês Aparecida Bianchi dos, Arns, Clarice Weis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432127/
https://www.ncbi.nlm.nih.gov/pubmed/34942156
http://dx.doi.org/10.1016/j.jped.2021.11.006
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author Bastos, Juliana Cristina Santiago
Simas, Paulo Vitor Marques
Caserta, Leonardo Cardia
Bragunde, Alfonso Eduardo Alvarez
Marson, Fernando Augusto de Lima
Martini, Matheus Cavalheiro
Padilla, Marina Aiello
Ribeiro, José Dirceu
Santos, Márcia Mercês Aparecida Bianchi dos
Arns, Clarice Weis
author_facet Bastos, Juliana Cristina Santiago
Simas, Paulo Vitor Marques
Caserta, Leonardo Cardia
Bragunde, Alfonso Eduardo Alvarez
Marson, Fernando Augusto de Lima
Martini, Matheus Cavalheiro
Padilla, Marina Aiello
Ribeiro, José Dirceu
Santos, Márcia Mercês Aparecida Bianchi dos
Arns, Clarice Weis
author_sort Bastos, Juliana Cristina Santiago
collection PubMed
description OBJECTIVES: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. METHOD: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in three hospitals in the Campinas Metropolitan Region (CMR) during 2013-14. The data was statically evaluated by Pearson's chi-squared test with statistical significance of 0.05 and 95% confidence level. RESULTS: As expected, the most prevalent viruses detected were RSV A and B in 47% and 16% of the samples, respectively. However, almost a third of severe bronchiolitis cases there were no detection of RSV, and the viruses more commonly detected were rhinoviruses, which were identified in almost a quarter of all positive samples for at least a viral agent. CONCLUSIONS: Although nothing could be concluded from the disease severity and clinical-epidemiological data, the present study's results indicate that severe bronchiolitis is not always related to RSV infections in children younger than two years old, and the rhinoviruses were more prevalent in these cases. These findings reinforce the need to carry out a viral diagnosis in the hospital emergency would be very appropriate for all cases of respiratory infections in children, even for diseases in which the primary etiological agent seems to be well known.
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spelling pubmed-94321272022-09-08 Rhinoviruses as critical agents in severe bronchiolitis in infants Bastos, Juliana Cristina Santiago Simas, Paulo Vitor Marques Caserta, Leonardo Cardia Bragunde, Alfonso Eduardo Alvarez Marson, Fernando Augusto de Lima Martini, Matheus Cavalheiro Padilla, Marina Aiello Ribeiro, José Dirceu Santos, Márcia Mercês Aparecida Bianchi dos Arns, Clarice Weis J Pediatr (Rio J) Original Article OBJECTIVES: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. METHOD: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in three hospitals in the Campinas Metropolitan Region (CMR) during 2013-14. The data was statically evaluated by Pearson's chi-squared test with statistical significance of 0.05 and 95% confidence level. RESULTS: As expected, the most prevalent viruses detected were RSV A and B in 47% and 16% of the samples, respectively. However, almost a third of severe bronchiolitis cases there were no detection of RSV, and the viruses more commonly detected were rhinoviruses, which were identified in almost a quarter of all positive samples for at least a viral agent. CONCLUSIONS: Although nothing could be concluded from the disease severity and clinical-epidemiological data, the present study's results indicate that severe bronchiolitis is not always related to RSV infections in children younger than two years old, and the rhinoviruses were more prevalent in these cases. These findings reinforce the need to carry out a viral diagnosis in the hospital emergency would be very appropriate for all cases of respiratory infections in children, even for diseases in which the primary etiological agent seems to be well known. Elsevier 2021-12-20 /pmc/articles/PMC9432127/ /pubmed/34942156 http://dx.doi.org/10.1016/j.jped.2021.11.006 Text en © 2022 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Bastos, Juliana Cristina Santiago
Simas, Paulo Vitor Marques
Caserta, Leonardo Cardia
Bragunde, Alfonso Eduardo Alvarez
Marson, Fernando Augusto de Lima
Martini, Matheus Cavalheiro
Padilla, Marina Aiello
Ribeiro, José Dirceu
Santos, Márcia Mercês Aparecida Bianchi dos
Arns, Clarice Weis
Rhinoviruses as critical agents in severe bronchiolitis in infants
title Rhinoviruses as critical agents in severe bronchiolitis in infants
title_full Rhinoviruses as critical agents in severe bronchiolitis in infants
title_fullStr Rhinoviruses as critical agents in severe bronchiolitis in infants
title_full_unstemmed Rhinoviruses as critical agents in severe bronchiolitis in infants
title_short Rhinoviruses as critical agents in severe bronchiolitis in infants
title_sort rhinoviruses as critical agents in severe bronchiolitis in infants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432127/
https://www.ncbi.nlm.nih.gov/pubmed/34942156
http://dx.doi.org/10.1016/j.jped.2021.11.006
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