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Rhinoviruses as critical agents in severe bronchiolitis in infants
OBJECTIVES: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. METHOD: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432127/ https://www.ncbi.nlm.nih.gov/pubmed/34942156 http://dx.doi.org/10.1016/j.jped.2021.11.006 |
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author | Bastos, Juliana Cristina Santiago Simas, Paulo Vitor Marques Caserta, Leonardo Cardia Bragunde, Alfonso Eduardo Alvarez Marson, Fernando Augusto de Lima Martini, Matheus Cavalheiro Padilla, Marina Aiello Ribeiro, José Dirceu Santos, Márcia Mercês Aparecida Bianchi dos Arns, Clarice Weis |
author_facet | Bastos, Juliana Cristina Santiago Simas, Paulo Vitor Marques Caserta, Leonardo Cardia Bragunde, Alfonso Eduardo Alvarez Marson, Fernando Augusto de Lima Martini, Matheus Cavalheiro Padilla, Marina Aiello Ribeiro, José Dirceu Santos, Márcia Mercês Aparecida Bianchi dos Arns, Clarice Weis |
author_sort | Bastos, Juliana Cristina Santiago |
collection | PubMed |
description | OBJECTIVES: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. METHOD: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in three hospitals in the Campinas Metropolitan Region (CMR) during 2013-14. The data was statically evaluated by Pearson's chi-squared test with statistical significance of 0.05 and 95% confidence level. RESULTS: As expected, the most prevalent viruses detected were RSV A and B in 47% and 16% of the samples, respectively. However, almost a third of severe bronchiolitis cases there were no detection of RSV, and the viruses more commonly detected were rhinoviruses, which were identified in almost a quarter of all positive samples for at least a viral agent. CONCLUSIONS: Although nothing could be concluded from the disease severity and clinical-epidemiological data, the present study's results indicate that severe bronchiolitis is not always related to RSV infections in children younger than two years old, and the rhinoviruses were more prevalent in these cases. These findings reinforce the need to carry out a viral diagnosis in the hospital emergency would be very appropriate for all cases of respiratory infections in children, even for diseases in which the primary etiological agent seems to be well known. |
format | Online Article Text |
id | pubmed-9432127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94321272022-09-08 Rhinoviruses as critical agents in severe bronchiolitis in infants Bastos, Juliana Cristina Santiago Simas, Paulo Vitor Marques Caserta, Leonardo Cardia Bragunde, Alfonso Eduardo Alvarez Marson, Fernando Augusto de Lima Martini, Matheus Cavalheiro Padilla, Marina Aiello Ribeiro, José Dirceu Santos, Márcia Mercês Aparecida Bianchi dos Arns, Clarice Weis J Pediatr (Rio J) Original Article OBJECTIVES: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. METHOD: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in three hospitals in the Campinas Metropolitan Region (CMR) during 2013-14. The data was statically evaluated by Pearson's chi-squared test with statistical significance of 0.05 and 95% confidence level. RESULTS: As expected, the most prevalent viruses detected were RSV A and B in 47% and 16% of the samples, respectively. However, almost a third of severe bronchiolitis cases there were no detection of RSV, and the viruses more commonly detected were rhinoviruses, which were identified in almost a quarter of all positive samples for at least a viral agent. CONCLUSIONS: Although nothing could be concluded from the disease severity and clinical-epidemiological data, the present study's results indicate that severe bronchiolitis is not always related to RSV infections in children younger than two years old, and the rhinoviruses were more prevalent in these cases. These findings reinforce the need to carry out a viral diagnosis in the hospital emergency would be very appropriate for all cases of respiratory infections in children, even for diseases in which the primary etiological agent seems to be well known. Elsevier 2021-12-20 /pmc/articles/PMC9432127/ /pubmed/34942156 http://dx.doi.org/10.1016/j.jped.2021.11.006 Text en © 2022 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Bastos, Juliana Cristina Santiago Simas, Paulo Vitor Marques Caserta, Leonardo Cardia Bragunde, Alfonso Eduardo Alvarez Marson, Fernando Augusto de Lima Martini, Matheus Cavalheiro Padilla, Marina Aiello Ribeiro, José Dirceu Santos, Márcia Mercês Aparecida Bianchi dos Arns, Clarice Weis Rhinoviruses as critical agents in severe bronchiolitis in infants |
title | Rhinoviruses as critical agents in severe bronchiolitis in infants |
title_full | Rhinoviruses as critical agents in severe bronchiolitis in infants |
title_fullStr | Rhinoviruses as critical agents in severe bronchiolitis in infants |
title_full_unstemmed | Rhinoviruses as critical agents in severe bronchiolitis in infants |
title_short | Rhinoviruses as critical agents in severe bronchiolitis in infants |
title_sort | rhinoviruses as critical agents in severe bronchiolitis in infants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432127/ https://www.ncbi.nlm.nih.gov/pubmed/34942156 http://dx.doi.org/10.1016/j.jped.2021.11.006 |
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