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Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study
OBJECTIVES: To contribute to a better understanding of the maternal genetic mechanisms that influence obstetric outcomes and that are involved in maternal and child health, this study aimed to evaluate the association between maternal genetic variants and the offspring birth weight by analyzing sing...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432150/ https://www.ncbi.nlm.nih.gov/pubmed/34508664 http://dx.doi.org/10.1016/j.jped.2021.06.007 |
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author | Alves, Lyvia Neves Rebello Pereira, Marcos dos Santos, Jéssica Aflávio dos Santos, Eldamária de Vargas Wolfgramm Carvalho, Gisele Queiroz Santana, Jerusa da Mota Tavares, Eric Arrivabene Fernandes, Marcilio Delan Baliza dos Santos, Djanilson Barbosa Louro, Iúri Drumond |
author_facet | Alves, Lyvia Neves Rebello Pereira, Marcos dos Santos, Jéssica Aflávio dos Santos, Eldamária de Vargas Wolfgramm Carvalho, Gisele Queiroz Santana, Jerusa da Mota Tavares, Eric Arrivabene Fernandes, Marcilio Delan Baliza dos Santos, Djanilson Barbosa Louro, Iúri Drumond |
author_sort | Alves, Lyvia Neves Rebello |
collection | PubMed |
description | OBJECTIVES: To contribute to a better understanding of the maternal genetic mechanisms that influence obstetric outcomes and that are involved in maternal and child health, this study aimed to evaluate the association between maternal genetic variants and the offspring birth weight by analyzing single-nucleotide polymorphisms (SNPs) in genes related to glucose homeostasis. METHODS: Three polymorphisms were analyzed (GCK rs1799884, TCF7L2 rs7903146 and LEPR rs1137101) in 250 pregnant women who participated in a Brazilian prospective cohort study. Genotyping was performed by Real-Time Polymerase Chain Reaction (qPCR) using pre-designed TaqMan® SNP genotyping assays. Vitamin D dosage was performed by chemiluminescence. Variance, Pearson's chi-square test and multiple linear regression were used for the statistical analysis. RESULTS: It was possible to verify a significant association between birth weight and maternal GCK rs1799884 when obstetric outcomes, clinical and anthropometric characteristics were taken into consideration. The children of homozygous women for the minor allele GCK rs1799884 presented lower birth weight (β = -335.25, 95% CI = -669.39; -1.17, p = 0.04). Furthermore, a direct link between a leptin receptor variant and gestational duration was found (p = 0.037). CONCLUSION: The variant GCK rs1799884 (mm) was associated with a reduction in newborn weight in the miscegenated Brazilian population. |
format | Online Article Text |
id | pubmed-9432150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94321502022-09-08 Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study Alves, Lyvia Neves Rebello Pereira, Marcos dos Santos, Jéssica Aflávio dos Santos, Eldamária de Vargas Wolfgramm Carvalho, Gisele Queiroz Santana, Jerusa da Mota Tavares, Eric Arrivabene Fernandes, Marcilio Delan Baliza dos Santos, Djanilson Barbosa Louro, Iúri Drumond J Pediatr (Rio J) Original Article OBJECTIVES: To contribute to a better understanding of the maternal genetic mechanisms that influence obstetric outcomes and that are involved in maternal and child health, this study aimed to evaluate the association between maternal genetic variants and the offspring birth weight by analyzing single-nucleotide polymorphisms (SNPs) in genes related to glucose homeostasis. METHODS: Three polymorphisms were analyzed (GCK rs1799884, TCF7L2 rs7903146 and LEPR rs1137101) in 250 pregnant women who participated in a Brazilian prospective cohort study. Genotyping was performed by Real-Time Polymerase Chain Reaction (qPCR) using pre-designed TaqMan® SNP genotyping assays. Vitamin D dosage was performed by chemiluminescence. Variance, Pearson's chi-square test and multiple linear regression were used for the statistical analysis. RESULTS: It was possible to verify a significant association between birth weight and maternal GCK rs1799884 when obstetric outcomes, clinical and anthropometric characteristics were taken into consideration. The children of homozygous women for the minor allele GCK rs1799884 presented lower birth weight (β = -335.25, 95% CI = -669.39; -1.17, p = 0.04). Furthermore, a direct link between a leptin receptor variant and gestational duration was found (p = 0.037). CONCLUSION: The variant GCK rs1799884 (mm) was associated with a reduction in newborn weight in the miscegenated Brazilian population. Elsevier 2021-09-09 /pmc/articles/PMC9432150/ /pubmed/34508664 http://dx.doi.org/10.1016/j.jped.2021.06.007 Text en © 2021 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Alves, Lyvia Neves Rebello Pereira, Marcos dos Santos, Jéssica Aflávio dos Santos, Eldamária de Vargas Wolfgramm Carvalho, Gisele Queiroz Santana, Jerusa da Mota Tavares, Eric Arrivabene Fernandes, Marcilio Delan Baliza dos Santos, Djanilson Barbosa Louro, Iúri Drumond Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study |
title | Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study |
title_full | Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study |
title_fullStr | Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study |
title_full_unstemmed | Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study |
title_short | Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study |
title_sort | investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432150/ https://www.ncbi.nlm.nih.gov/pubmed/34508664 http://dx.doi.org/10.1016/j.jped.2021.06.007 |
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