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만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가
PURPOSE: This study aimed to compare the brain perfusion status of patients with chronic kidney disease to a normal control group to identify any significant differences. MATERIALS AND METHODS: The perfusion state of the brain was measured by MRI using the arterial spin labeling technique in 36 pati...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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The Korean Society of Radiology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432203/ https://www.ncbi.nlm.nih.gov/pubmed/36238175 http://dx.doi.org/10.3348/jksr.2020.81.4.912 |
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collection | PubMed |
description | PURPOSE: This study aimed to compare the brain perfusion status of patients with chronic kidney disease to a normal control group to identify any significant differences. MATERIALS AND METHODS: The perfusion state of the brain was measured by MRI using the arterial spin labeling technique in 36 patients undergoing hemodialysis due to chronic kidney disease and 36 normal controls. Images were then analyzed in a voxel-wise manner to detect brain areas showing significant perfusion differences between the two groups. RESULTS: Patients with chronic kidney disease showed increased perfusion in the form of large clusters across the right fronto-parieto-temporal lobe and the left parieto-occipital lobe. In addition, perfusion increased in the bilateral thalami, midbrain, pons, and cerebellum (p < 0.01, family-wise error corrected). CONCLUSION: Brain perfusion appears to increase in patients with chronic kidney disease compared to normal controls. Uremic toxicity is thought to be the cause of this increase as it can cause damage to the microscopic blood vessels and their surrounding structures. |
format | Online Article Text |
id | pubmed-9432203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Society of Radiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-94322032022-10-12 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 Taehan Yongsang Uihakhoe Chi Neuroradiology & Neurointervention PURPOSE: This study aimed to compare the brain perfusion status of patients with chronic kidney disease to a normal control group to identify any significant differences. MATERIALS AND METHODS: The perfusion state of the brain was measured by MRI using the arterial spin labeling technique in 36 patients undergoing hemodialysis due to chronic kidney disease and 36 normal controls. Images were then analyzed in a voxel-wise manner to detect brain areas showing significant perfusion differences between the two groups. RESULTS: Patients with chronic kidney disease showed increased perfusion in the form of large clusters across the right fronto-parieto-temporal lobe and the left parieto-occipital lobe. In addition, perfusion increased in the bilateral thalami, midbrain, pons, and cerebellum (p < 0.01, family-wise error corrected). CONCLUSION: Brain perfusion appears to increase in patients with chronic kidney disease compared to normal controls. Uremic toxicity is thought to be the cause of this increase as it can cause damage to the microscopic blood vessels and their surrounding structures. The Korean Society of Radiology 2020-07 2020-07-30 /pmc/articles/PMC9432203/ /pubmed/36238175 http://dx.doi.org/10.3348/jksr.2020.81.4.912 Text en Copyrights © 2020 The Korean Society of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroradiology & Neurointervention 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 |
title | 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 |
title_full | 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 |
title_fullStr | 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 |
title_full_unstemmed | 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 |
title_short | 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 |
title_sort | 만성 콩팥병 환자들에서 동맥 스핀 표지 기법을 이용한 뇌 관류상태의 평가 |
topic | Neuroradiology & Neurointervention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432203/ https://www.ncbi.nlm.nih.gov/pubmed/36238175 http://dx.doi.org/10.3348/jksr.2020.81.4.912 |
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