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Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life
OBJECTIVE: Serum levels of creatinine in neonates are quite variable and suffer interference from the immature kidney and maternal creatinine concentration. The aim of this study was to measure novel biomarkers of glomerular and tubular function in healthy preterm neonates at 72 h and 3 weeks of lif...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432259/ https://www.ncbi.nlm.nih.gov/pubmed/33358961 http://dx.doi.org/10.1016/j.jped.2020.11.006 |
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author | Correa, Luisa Petri Marzano, Alessandra Cristina Santos Silva Filha, Roberta Magalhães, Rafael Coelho Simoes-e-Silva, Ana Cristina |
author_facet | Correa, Luisa Petri Marzano, Alessandra Cristina Santos Silva Filha, Roberta Magalhães, Rafael Coelho Simoes-e-Silva, Ana Cristina |
author_sort | Correa, Luisa Petri |
collection | PubMed |
description | OBJECTIVE: Serum levels of creatinine in neonates are quite variable and suffer interference from the immature kidney and maternal creatinine concentration. The aim of this study was to measure novel biomarkers of glomerular and tubular function in healthy preterm neonates at 72 h and 3 weeks of life. METHODS: Urine samples were collected in 40 preterm neonates with 28–34 incomplete weeks of gestational age. None of the participants had comorbidities, malformations and infections. The samples were collected at 72 h of life and at 3 weeks after birth. Measurements of Calbindin, Collagen IV, FABP1, αGST, IP-10, KIM-1, Osteoactivin, Renin, TFF-3, TIMP-1, α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL and Osteopontin were performed using panels 1 and 2 of multiplex kits of kidney injury. Data were analyzed using the software GraphPad Prism version 6.0. RESULTS: The preterm neonates included 55% of males with gestational age of 30 ± 1 weeks. The most frequent maternal condition associated with preterm birth was preeclampsia (80%). Molecules related to glomerular function showed a significant increase in the concentrations obtained at 3 weeks of life compared to 72 h of life. Markers related to tubular injury (KIM-1 and NGAL) also showed an increase. On the other hand, cystatin C did not change. CONCLUSION: The elevation of molecules related to glomerular function indicates an increase of glomerular filtration rate from 72 h up until 3 weeks of life, which was not clearly detected with the measurement of cystatin C. |
format | Online Article Text |
id | pubmed-9432259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94322592022-09-08 Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life Correa, Luisa Petri Marzano, Alessandra Cristina Santos Silva Filha, Roberta Magalhães, Rafael Coelho Simoes-e-Silva, Ana Cristina J Pediatr (Rio J) Original Article OBJECTIVE: Serum levels of creatinine in neonates are quite variable and suffer interference from the immature kidney and maternal creatinine concentration. The aim of this study was to measure novel biomarkers of glomerular and tubular function in healthy preterm neonates at 72 h and 3 weeks of life. METHODS: Urine samples were collected in 40 preterm neonates with 28–34 incomplete weeks of gestational age. None of the participants had comorbidities, malformations and infections. The samples were collected at 72 h of life and at 3 weeks after birth. Measurements of Calbindin, Collagen IV, FABP1, αGST, IP-10, KIM-1, Osteoactivin, Renin, TFF-3, TIMP-1, α-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL and Osteopontin were performed using panels 1 and 2 of multiplex kits of kidney injury. Data were analyzed using the software GraphPad Prism version 6.0. RESULTS: The preterm neonates included 55% of males with gestational age of 30 ± 1 weeks. The most frequent maternal condition associated with preterm birth was preeclampsia (80%). Molecules related to glomerular function showed a significant increase in the concentrations obtained at 3 weeks of life compared to 72 h of life. Markers related to tubular injury (KIM-1 and NGAL) also showed an increase. On the other hand, cystatin C did not change. CONCLUSION: The elevation of molecules related to glomerular function indicates an increase of glomerular filtration rate from 72 h up until 3 weeks of life, which was not clearly detected with the measurement of cystatin C. Elsevier 2020-12-24 /pmc/articles/PMC9432259/ /pubmed/33358961 http://dx.doi.org/10.1016/j.jped.2020.11.006 Text en © 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Correa, Luisa Petri Marzano, Alessandra Cristina Santos Silva Filha, Roberta Magalhães, Rafael Coelho Simoes-e-Silva, Ana Cristina Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life |
title | Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life |
title_full | Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life |
title_fullStr | Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life |
title_full_unstemmed | Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life |
title_short | Biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life |
title_sort | biomarkers of renal function in preterm neonates at 72 h and 3 weeks of life |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432259/ https://www.ncbi.nlm.nih.gov/pubmed/33358961 http://dx.doi.org/10.1016/j.jped.2020.11.006 |
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