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Irritable bowel syndrome in Indonesian adolescents
OBJECTIVE: Irritable bowel syndrome is a frequent functional gastrointestinal disorder. The aims of this study were to investigate its epidemiology, focusing on the role of intestinal mucosal integrity and to evaluate the impact on the quality of life. METHODS: A community-based survey applying a co...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432273/ https://www.ncbi.nlm.nih.gov/pubmed/32156535 http://dx.doi.org/10.1016/j.jped.2020.02.001 |
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author | Kesuma, Yudianita Sekartini, Rini Timan, Ina S. Kurniawan, Agnes Bardosono, Saptawati Firmansyah, Agus Vandenplas, Yvan |
author_facet | Kesuma, Yudianita Sekartini, Rini Timan, Ina S. Kurniawan, Agnes Bardosono, Saptawati Firmansyah, Agus Vandenplas, Yvan |
author_sort | Kesuma, Yudianita |
collection | PubMed |
description | OBJECTIVE: Irritable bowel syndrome is a frequent functional gastrointestinal disorder. The aims of this study were to investigate its epidemiology, focusing on the role of intestinal mucosal integrity and to evaluate the impact on the quality of life. METHODS: A community-based survey applying a comparative cross sectional approach was conducted in six high schools in Palembang. Subjects were recruited using multistage random sampling divided in two groups. Rome III criteria were used to establish a diagnosis of IBS in combination with a questionnaire to determine risk factors. Determination of fecal alpha-1-antitrypsin and calprotectin levels was performed to determine impaired intestinal mucosal integrity. A questionnaire was used to evaluate how quality of life was affected by irritable bowel syndrome. RESULTS: The survey was performed in 454 14−18 years old adolescents, of whom 30.2% fulfilled the Rome III criteria for IBS, with the following subtypes: 36.5% diarrhea, 18.9% constipation, 21.9% mixed, and 22.6% unclassified. Major risk factors were female gender, bullying, age 14–16 years, history of constipation and diarrhea, eating nuts, and drinking coffee, tea, and soft drinks. There was a significant association with intestinal inflammation (p = 0.013). A significantly impaired quality of life was found (p = 0.001). CONCLUSIONS: The prevalence of irritable bowel syndrome in adolescents was high, with bullying, female gender, age 14–16 years, constipation and diarrhea, and dietary consumption of soft drinks, coffee, and tea as risk factors. A significant association with intestinal inflammation was found. |
format | Online Article Text |
id | pubmed-9432273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94322732022-09-08 Irritable bowel syndrome in Indonesian adolescents Kesuma, Yudianita Sekartini, Rini Timan, Ina S. Kurniawan, Agnes Bardosono, Saptawati Firmansyah, Agus Vandenplas, Yvan J Pediatr (Rio J) Original Article OBJECTIVE: Irritable bowel syndrome is a frequent functional gastrointestinal disorder. The aims of this study were to investigate its epidemiology, focusing on the role of intestinal mucosal integrity and to evaluate the impact on the quality of life. METHODS: A community-based survey applying a comparative cross sectional approach was conducted in six high schools in Palembang. Subjects were recruited using multistage random sampling divided in two groups. Rome III criteria were used to establish a diagnosis of IBS in combination with a questionnaire to determine risk factors. Determination of fecal alpha-1-antitrypsin and calprotectin levels was performed to determine impaired intestinal mucosal integrity. A questionnaire was used to evaluate how quality of life was affected by irritable bowel syndrome. RESULTS: The survey was performed in 454 14−18 years old adolescents, of whom 30.2% fulfilled the Rome III criteria for IBS, with the following subtypes: 36.5% diarrhea, 18.9% constipation, 21.9% mixed, and 22.6% unclassified. Major risk factors were female gender, bullying, age 14–16 years, history of constipation and diarrhea, eating nuts, and drinking coffee, tea, and soft drinks. There was a significant association with intestinal inflammation (p = 0.013). A significantly impaired quality of life was found (p = 0.001). CONCLUSIONS: The prevalence of irritable bowel syndrome in adolescents was high, with bullying, female gender, age 14–16 years, constipation and diarrhea, and dietary consumption of soft drinks, coffee, and tea as risk factors. A significant association with intestinal inflammation was found. Elsevier 2020-03-08 /pmc/articles/PMC9432273/ /pubmed/32156535 http://dx.doi.org/10.1016/j.jped.2020.02.001 Text en © 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Kesuma, Yudianita Sekartini, Rini Timan, Ina S. Kurniawan, Agnes Bardosono, Saptawati Firmansyah, Agus Vandenplas, Yvan Irritable bowel syndrome in Indonesian adolescents |
title | Irritable bowel syndrome in Indonesian adolescents |
title_full | Irritable bowel syndrome in Indonesian adolescents |
title_fullStr | Irritable bowel syndrome in Indonesian adolescents |
title_full_unstemmed | Irritable bowel syndrome in Indonesian adolescents |
title_short | Irritable bowel syndrome in Indonesian adolescents |
title_sort | irritable bowel syndrome in indonesian adolescents |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432273/ https://www.ncbi.nlm.nih.gov/pubmed/32156535 http://dx.doi.org/10.1016/j.jped.2020.02.001 |
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