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Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report
Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of influenza-associated encephalopathy characterized by symmetric multiple lesions with an invariable thalamic involvement. Although the exact pathogenesis of ANE remains unclear, the most prevalent hypothesis is the “cytokine sto...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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The Korean Society of Radiology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432353/ https://www.ncbi.nlm.nih.gov/pubmed/36238398 http://dx.doi.org/10.3348/jksr.2020.0173 |
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collection | PubMed |
description | Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of influenza-associated encephalopathy characterized by symmetric multiple lesions with an invariable thalamic involvement. Although the exact pathogenesis of ANE remains unclear, the most prevalent hypothesis is the “cytokine storm,” which results in blood-brain-barrier breakdown. We present the case of a 10-year-old boy with fulminant ANE confirmed with serial MRI studies, including diffusion-weighted imaging and susceptibility-weighted imaging. A comparison of these serial images demonstrated detailed and longitudinal changes in MRI findings during the clinical course corresponding to pathophysiological changes. Our case clarifies the pathogenesis of ANE brain lesions using serial imaging studies and suggests that early immunomodulatory therapy reduces brain damage. |
format | Online Article Text |
id | pubmed-9432353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Society of Radiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-94323532022-10-12 Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report Taehan Yongsang Uihakhoe Chi Neuroradiology & Neurointervention Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of influenza-associated encephalopathy characterized by symmetric multiple lesions with an invariable thalamic involvement. Although the exact pathogenesis of ANE remains unclear, the most prevalent hypothesis is the “cytokine storm,” which results in blood-brain-barrier breakdown. We present the case of a 10-year-old boy with fulminant ANE confirmed with serial MRI studies, including diffusion-weighted imaging and susceptibility-weighted imaging. A comparison of these serial images demonstrated detailed and longitudinal changes in MRI findings during the clinical course corresponding to pathophysiological changes. Our case clarifies the pathogenesis of ANE brain lesions using serial imaging studies and suggests that early immunomodulatory therapy reduces brain damage. The Korean Society of Radiology 2021-09 2021-07-14 /pmc/articles/PMC9432353/ /pubmed/36238398 http://dx.doi.org/10.3348/jksr.2020.0173 Text en Copyrights © 2021 The Korean Society of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroradiology & Neurointervention Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report |
title | Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report |
title_full | Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report |
title_fullStr | Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report |
title_full_unstemmed | Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report |
title_short | Fulminant Course of Acute Necrotizing Encephalopathy Followed by Serial MRI: A Case Report |
title_sort | fulminant course of acute necrotizing encephalopathy followed by serial mri: a case report |
topic | Neuroradiology & Neurointervention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432353/ https://www.ncbi.nlm.nih.gov/pubmed/36238398 http://dx.doi.org/10.3348/jksr.2020.0173 |
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