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The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis

BACKGROUND: Multiple sclerosis is the most prevalent neurological disability of young adults. Anti-inflammatory drugs have relative effects on MS. The anti-inflammatory and antioxidative effects of Zingiber officinale (ginger) have been proven in some experimental and clinical investigations. The ai...

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Autores principales: Moradi, Valiollah, Esfandiary, Ebrahim, Ghanadian, Mustafa, Ghasemi, Nazem, Rashidi, Bahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432465/
https://www.ncbi.nlm.nih.gov/pubmed/36029169
http://dx.doi.org/10.52547/ibj.2979
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author Moradi, Valiollah
Esfandiary, Ebrahim
Ghanadian, Mustafa
Ghasemi, Nazem
Rashidi, Bahman
author_facet Moradi, Valiollah
Esfandiary, Ebrahim
Ghanadian, Mustafa
Ghasemi, Nazem
Rashidi, Bahman
author_sort Moradi, Valiollah
collection PubMed
description BACKGROUND: Multiple sclerosis is the most prevalent neurological disability of young adults. Anti-inflammatory drugs have relative effects on MS. The anti-inflammatory and antioxidative effects of Zingiber officinale (ginger) have been proven in some experimental and clinical investigations. The aim of this study was to evaluate the effects of ginger extract on preventing myelin degradation in a rat model of MS. METHODS: Forty nine male Wistar rats were used in this study and divided into four control groups: the normal group, cuprizone-induced group, sham group (CPZ + NaCMC), standard control group (fingolimod + cuprizone), including three experimental groups of CPZ, each receiving three different doses of ginger extract: 150, 300, and 600mg/kg /kg/day. RESULTS: Ginger extract of 600 mg/kg prevented CC from demyelination; however, a significant difference was observed in the fingolimod group (p < 0.05). Difference in the CPZ group was quite significant (p < 0.05). CONCLUSION: Treatment with ginger inhibited demyelination and alleviated remyelination of corpus callosum in rats. Therefore, it could serve as a therapeutic agent in the MS.
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spelling pubmed-94324652022-09-13 The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis Moradi, Valiollah Esfandiary, Ebrahim Ghanadian, Mustafa Ghasemi, Nazem Rashidi, Bahman Iran Biomed J Full Length BACKGROUND: Multiple sclerosis is the most prevalent neurological disability of young adults. Anti-inflammatory drugs have relative effects on MS. The anti-inflammatory and antioxidative effects of Zingiber officinale (ginger) have been proven in some experimental and clinical investigations. The aim of this study was to evaluate the effects of ginger extract on preventing myelin degradation in a rat model of MS. METHODS: Forty nine male Wistar rats were used in this study and divided into four control groups: the normal group, cuprizone-induced group, sham group (CPZ + NaCMC), standard control group (fingolimod + cuprizone), including three experimental groups of CPZ, each receiving three different doses of ginger extract: 150, 300, and 600mg/kg /kg/day. RESULTS: Ginger extract of 600 mg/kg prevented CC from demyelination; however, a significant difference was observed in the fingolimod group (p < 0.05). Difference in the CPZ group was quite significant (p < 0.05). CONCLUSION: Treatment with ginger inhibited demyelination and alleviated remyelination of corpus callosum in rats. Therefore, it could serve as a therapeutic agent in the MS. Pasteur Institute of Iran 2022-07 2022-08-27 /pmc/articles/PMC9432465/ /pubmed/36029169 http://dx.doi.org/10.52547/ibj.2979 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Length
Moradi, Valiollah
Esfandiary, Ebrahim
Ghanadian, Mustafa
Ghasemi, Nazem
Rashidi, Bahman
The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
title The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
title_full The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
title_fullStr The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
title_full_unstemmed The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
title_short The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
title_sort effect of zingiber officinale extract on preventing demyelination of corpus callosum in a rat model of multiple sclerosis
topic Full Length
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432465/
https://www.ncbi.nlm.nih.gov/pubmed/36029169
http://dx.doi.org/10.52547/ibj.2979
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