Interrogation of T Cell–enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism

Metabolic features of the tumor microenvironment (TME) antagonize antitumor immunity. We hypothesized that T cell–infiltrated (Thi) tumors with a known antigen should exhibit superior clinical outcomes, though some fare worse given unfavorable metabolic features leveraging T cell–infiltrated (Thi),...

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Detalles Bibliográficos
Autores principales: Harbison, R. Alex, Pandey, Rajeev, Considine, Michael, Leone, Robert D., Murray-Stewart, Tracy, Erbe, Rossin, Mandal, Raj, Burns, Mark, Casero, Robert A., Seiwert, Tanguy, Fakhry, Carole, Pardoll, Drew, Fertig, Elana, Powell, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432485/
https://www.ncbi.nlm.nih.gov/pubmed/36052016
http://dx.doi.org/10.1158/2767-9764.CRC-22-0061

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