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Functionally impaired isoforms regulate TMPRSS6 proteolytic activity

TMPRSS6 is a type II transmembrane serine protease involved in iron homeostasis expressed as 4 isoforms in humans. TMPRSS6 isoform 2 downregulates hepcidin production by cleaving hemojuvelin and other surface proteins of hepatocytes. The functions of catalytically impaired isoforms 3 and 4 are still...

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Detalles Bibliográficos
Autores principales:	Dion, Sébastien P., Désilets, Antoine, Lemieux, Gabriel, Leduc, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432768/ https://www.ncbi.nlm.nih.gov/pubmed/36044454 http://dx.doi.org/10.1371/journal.pone.0273825

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