Successful infusional 5-fluorouracil administration in a patient with vasospastic angina

A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has...

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Detalles Bibliográficos
Autores principales: Tai, Shannon, Mohananey, Divyanshu, Griffiths, Claire, Johnson, Bradley, Garg, Jalaj, Ridolfi, Timothy J., Lohr, Nicole L., Chakrabarti, Sakti, Brown, Sherry-Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432777/
https://www.ncbi.nlm.nih.gov/pubmed/36051246
http://dx.doi.org/10.1016/j.ahjo.2022.100147
Descripción
Sumario:A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has been reported to produce severe cardiotoxic side effects, including coronary vasospasm, ventricular arrhythmias, and sudden cardiac death, and is not typically reported in individuals with pre-existing coronary vasospasm.

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