In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors

In mice and humans with cancer, intravenous (13)C-glucose infusion results in (13)C labeling of tumor tricarboxylic acid (TCA) cycle intermediates, indicating that pyruvate oxidation in the TCA cycle occurs in tumors. The TCA cycle is usually coupled to the electron transport chain (ETC) because NAD...

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Detalles Bibliográficos
Autores principales: Pachnis, Panayotis, Wu, Zheng, Faubert, Brandon, Tasdogan, Alpaslan, Gu, Wen, Shelton, Spencer, Solmonson, Ashley, Rao, Aparna D., Kaushik, Akash K., Rogers, Thomas J., Ubellacker, Jessalyn M., LaVigne, Collette A., Yang, Chendong, Ko, Bookyung, Ramesh, Vijayashree, Sudderth, Jessica, Zacharias, Lauren G., Martin-Sandoval, Misty S., Do, Duyen, Mathews, Thomas P., Zhao, Zhiyu, Mishra, Prashant, Morrison, Sean J., DeBerardinis, Ralph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432826/
https://www.ncbi.nlm.nih.gov/pubmed/36044570
http://dx.doi.org/10.1126/sciadv.abn9550

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