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Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity

The ventromedial hypothalamus (VMH) is known to regulate body weight and counterregulatory response. However, how VMH neurons regulate lipid metabolism and energy balance remains unknown. O-linked β-d-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), catalyzed by O-GlcNAc transferase (O...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Zhang, Bichen, Stutz, Bernardo, Liu, Zhong-Wu, Horvath, Tamas L., Yang, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432828/
https://www.ncbi.nlm.nih.gov/pubmed/36044565
http://dx.doi.org/10.1126/sciadv.abn8092

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