JAG1-NOTCH4 mechanosensing drives atherosclerosis

Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arteries that causes heart attack and stroke, through poorly defined mechanisms. The Notch pathway plays a central role in blood vessel growth and homeostasis, but its potential role in sensing of disturbed...

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Detalles Bibliográficos
Autores principales: Souilhol, Celine, Tardajos Ayllon, Blanca, Li, Xiuying, Diagbouga, Mannekomba R., Zhou, Ziqi, Canham, Lindsay, Roddie, Hannah, Pirri, Daniela, Chambers, Emily V., Dunning, Mark J., Ariaans, Mark, Li, Jin, Fang, Yun, Jørgensen, Helle F., Simons, Michael, Krams, Rob, Waltenberger, Johannes, Fragiadaki, Maria, Ridger, Victoria, De Val, Sarah, Francis, Sheila E., Chico, Timothy JA, Serbanovic-Canic, Jovana, Evans, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432841/
https://www.ncbi.nlm.nih.gov/pubmed/36044575
http://dx.doi.org/10.1126/sciadv.abo7958

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