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Folic acid restricts SARS-CoV-2 invasion by methylating ACE2

The current COVID-19 pandemic is motivating us to elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility. We found that SARS-CoV-2 could increase the protein level of ACE2 in mice. Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR)...

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Autores principales: Zhang, Yuanzhou, Pang, Yechun, Xu, Baiyin, Chen, Xingshi, Liang, Shunshun, Hu, Jingying, Luo, Xiaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432853/
https://www.ncbi.nlm.nih.gov/pubmed/36060767
http://dx.doi.org/10.3389/fmicb.2022.980903
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author Zhang, Yuanzhou
Pang, Yechun
Xu, Baiyin
Chen, Xingshi
Liang, Shunshun
Hu, Jingying
Luo, Xiaoying
author_facet Zhang, Yuanzhou
Pang, Yechun
Xu, Baiyin
Chen, Xingshi
Liang, Shunshun
Hu, Jingying
Luo, Xiaoying
author_sort Zhang, Yuanzhou
collection PubMed
description The current COVID-19 pandemic is motivating us to elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility. We found that SARS-CoV-2 could increase the protein level of ACE2 in mice. Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2 promoter and inhibit ACE2 expression. Folic acid treatment decreased the binding ability of Spike protein, pseudovirus and inactivated authentic SARS-CoV-2 to host cells. Thus, folic acid treatment could decrease SARS-CoV-2 invasion and SARS-CoV-2-neutralizing antibody production in mice. These data suggest that increased intake of folic acid may inhibit ACE2 expression and reduce the transmissibility of SARS-CoV-2. Folic acid could play an important role in SARS-CoV-2 infection prevention and control.
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spelling pubmed-94328532022-09-01 Folic acid restricts SARS-CoV-2 invasion by methylating ACE2 Zhang, Yuanzhou Pang, Yechun Xu, Baiyin Chen, Xingshi Liang, Shunshun Hu, Jingying Luo, Xiaoying Front Microbiol Microbiology The current COVID-19 pandemic is motivating us to elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility. We found that SARS-CoV-2 could increase the protein level of ACE2 in mice. Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2 promoter and inhibit ACE2 expression. Folic acid treatment decreased the binding ability of Spike protein, pseudovirus and inactivated authentic SARS-CoV-2 to host cells. Thus, folic acid treatment could decrease SARS-CoV-2 invasion and SARS-CoV-2-neutralizing antibody production in mice. These data suggest that increased intake of folic acid may inhibit ACE2 expression and reduce the transmissibility of SARS-CoV-2. Folic acid could play an important role in SARS-CoV-2 infection prevention and control. Frontiers Media S.A. 2022-08-17 /pmc/articles/PMC9432853/ /pubmed/36060767 http://dx.doi.org/10.3389/fmicb.2022.980903 Text en Copyright © 2022 Zhang, Pang, Xu, Chen, Liang, Hu and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhang, Yuanzhou
Pang, Yechun
Xu, Baiyin
Chen, Xingshi
Liang, Shunshun
Hu, Jingying
Luo, Xiaoying
Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
title Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
title_full Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
title_fullStr Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
title_full_unstemmed Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
title_short Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
title_sort folic acid restricts sars-cov-2 invasion by methylating ace2
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432853/
https://www.ncbi.nlm.nih.gov/pubmed/36060767
http://dx.doi.org/10.3389/fmicb.2022.980903
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