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The role of protein kinase C in diabetic microvascular complications
Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox str...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433088/ https://www.ncbi.nlm.nih.gov/pubmed/36060954 http://dx.doi.org/10.3389/fendo.2022.973058 |
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author | Pan, Deng Xu, Lin Guo, Ming |
author_facet | Pan, Deng Xu, Lin Guo, Ming |
author_sort | Pan, Deng |
collection | PubMed |
description | Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox stress. As a result, various types of cells in the microvasculature are influenced, leading to changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening and angiogenesis. Structural and functional disorders further exacerbate diabetic microvascular complications. Here, we review the roles of PKC in the development of diabetic microvascular complications, presenting evidence from experiments and clinical trials. |
format | Online Article Text |
id | pubmed-9433088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94330882022-09-01 The role of protein kinase C in diabetic microvascular complications Pan, Deng Xu, Lin Guo, Ming Front Endocrinol (Lausanne) Endocrinology Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox stress. As a result, various types of cells in the microvasculature are influenced, leading to changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening and angiogenesis. Structural and functional disorders further exacerbate diabetic microvascular complications. Here, we review the roles of PKC in the development of diabetic microvascular complications, presenting evidence from experiments and clinical trials. Frontiers Media S.A. 2022-08-17 /pmc/articles/PMC9433088/ /pubmed/36060954 http://dx.doi.org/10.3389/fendo.2022.973058 Text en Copyright © 2022 Pan, Xu and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Pan, Deng Xu, Lin Guo, Ming The role of protein kinase C in diabetic microvascular complications |
title | The role of protein kinase C in diabetic microvascular complications |
title_full | The role of protein kinase C in diabetic microvascular complications |
title_fullStr | The role of protein kinase C in diabetic microvascular complications |
title_full_unstemmed | The role of protein kinase C in diabetic microvascular complications |
title_short | The role of protein kinase C in diabetic microvascular complications |
title_sort | role of protein kinase c in diabetic microvascular complications |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433088/ https://www.ncbi.nlm.nih.gov/pubmed/36060954 http://dx.doi.org/10.3389/fendo.2022.973058 |
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