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The role of protein kinase C in diabetic microvascular complications

Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox str...

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Detalles Bibliográficos
Autores principales: Pan, Deng, Xu, Lin, Guo, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433088/
https://www.ncbi.nlm.nih.gov/pubmed/36060954
http://dx.doi.org/10.3389/fendo.2022.973058
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author Pan, Deng
Xu, Lin
Guo, Ming
author_facet Pan, Deng
Xu, Lin
Guo, Ming
author_sort Pan, Deng
collection PubMed
description Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox stress. As a result, various types of cells in the microvasculature are influenced, leading to changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening and angiogenesis. Structural and functional disorders further exacerbate diabetic microvascular complications. Here, we review the roles of PKC in the development of diabetic microvascular complications, presenting evidence from experiments and clinical trials.
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spelling pubmed-94330882022-09-01 The role of protein kinase C in diabetic microvascular complications Pan, Deng Xu, Lin Guo, Ming Front Endocrinol (Lausanne) Endocrinology Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox stress. As a result, various types of cells in the microvasculature are influenced, leading to changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening and angiogenesis. Structural and functional disorders further exacerbate diabetic microvascular complications. Here, we review the roles of PKC in the development of diabetic microvascular complications, presenting evidence from experiments and clinical trials. Frontiers Media S.A. 2022-08-17 /pmc/articles/PMC9433088/ /pubmed/36060954 http://dx.doi.org/10.3389/fendo.2022.973058 Text en Copyright © 2022 Pan, Xu and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Pan, Deng
Xu, Lin
Guo, Ming
The role of protein kinase C in diabetic microvascular complications
title The role of protein kinase C in diabetic microvascular complications
title_full The role of protein kinase C in diabetic microvascular complications
title_fullStr The role of protein kinase C in diabetic microvascular complications
title_full_unstemmed The role of protein kinase C in diabetic microvascular complications
title_short The role of protein kinase C in diabetic microvascular complications
title_sort role of protein kinase c in diabetic microvascular complications
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433088/
https://www.ncbi.nlm.nih.gov/pubmed/36060954
http://dx.doi.org/10.3389/fendo.2022.973058
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