Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state

Omics-based technologies are driving major advances in precision medicine, but efforts are still required to consolidate their use in drug discovery. In this work, we exemplify the use of multi-omics to support the development of 3-chloropiperidines, a new class of candidate anticancer agents. Combi...

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Detalles Bibliográficos
Autores principales: Carraro, Caterina, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Horne, Arik, Oestreich, Marie, Warnat-Herresthal, Stefanie, Helbing, Tim, De Franco, Michele, Haendler, Kristian, Mukherjee, Sach, Ulas, Thomas, Gandin, Valentina, Goettlich, Richard, Aschenbrenner, Anna C, Schultze, Joachim L, Gatto, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433094/
https://www.ncbi.nlm.nih.gov/pubmed/36043458
http://dx.doi.org/10.7554/eLife.78012

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