Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An unbiased whole-genome methylome was studied in the wound-edge tissue of patients with chronic wounds. A total of 4,689 differentially methylated regions (DMRs) were identified in chronic wound-edge skin compared wi...

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Detalles Bibliográficos
Autores principales: Singh, Kanhaiya, Rustagi, Yashika, Abouhashem, Ahmed S., Tabasum, Saba, Verma, Priyanka, Hernandez, Edward, Pal, Durba, Khona, Dolly K., Mohanty, Sujit K., Kumar, Manishekhar, Srivastava, Rajneesh, Guda, Poornachander R., Verma, Sumit S., Mahajan, Sanskruti, Killian, Jackson A., Walker, Logan A., Ghatak, Subhadip, Mathew-Steiner, Shomita S., Wanczyk, Kristen E., Liu, Sheng, Wan, Jun, Yan, Pearlly, Bundschuh, Ralf, Khanna, Savita, Gordillo, Gayle M., Murphy, Michael P., Roy, Sashwati, Sen, Chandan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433101/
https://www.ncbi.nlm.nih.gov/pubmed/35819852
http://dx.doi.org/10.1172/JCI157279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433101/
https://www.ncbi.nlm.nih.gov/pubmed/35819852
http://dx.doi.org/10.1172/JCI157279

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