Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment

Cancer-related cognitive impairment (CRCI) is a major neurotoxicity affecting more than 50% of cancer survivors. The underpinning mechanisms are mostly unknown, and there are no FDA-approved interventions. Sphingolipidomic analysis of mouse prefrontal cortex and hippocampus, key sites of cognitive f...

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Detalles Bibliográficos
Autores principales: Squillace, Silvia, Niehoff, Michael L., Doyle, Timothy M., Green, Michael, Esposito, Emanuela, Cuzzocrea, Salvatore, Arnatt, Christopher K., Spiegel, Sarah, Farr, Susan A., Salvemini, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Concise Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433103/
https://www.ncbi.nlm.nih.gov/pubmed/36047496
http://dx.doi.org/10.1172/JCI157738

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