Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses

Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell–intrinsic molecular mechanisms of the immune-desert phenotype remain poorly under...

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Detalles Bibliográficos
Autores principales: Yan, Juan, Chen, Yuedan, Patel, Amish J., Warda, Sarah, Lee, Cindy J., Nixon, Briana G., Wong, Elissa W.P., Miranda-Román, Miguel A., Yang, Ning, Wang, Yi, Pachai, Mohini R., Sher, Jessica, Giff, Emily, Tang, Fanying, Khurana, Ekta, Singer, Sam, Liu, Yang, Galbo, Phillip M., Maag, Jesper L.V., Koche, Richard P., Zheng, Deyou, Antonescu, Cristina R., Deng, Liang, Li, Ming O., Chen, Yu, Chi, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433107/
https://www.ncbi.nlm.nih.gov/pubmed/35852856
http://dx.doi.org/10.1172/JCI153437

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