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Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
Dysregulated host response to infection, which cause life-threatening organ dysfunction, was defined as sepsis. Sepsis can cause acute and long-term brain dysfunction, namely, sepsis-associated encephalopathy (SAE) and cognitive impairment. SAE refers to changes in consciousness without direct evide...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433216/ https://www.ncbi.nlm.nih.gov/pubmed/36062193 http://dx.doi.org/10.1155/2022/1328729 |
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author | Pan, Shangwen Lv, Zheng Wang, Rui Shu, Huaqing Yuan, Shiying Yu, Yuan Shang, You |
author_facet | Pan, Shangwen Lv, Zheng Wang, Rui Shu, Huaqing Yuan, Shiying Yu, Yuan Shang, You |
author_sort | Pan, Shangwen |
collection | PubMed |
description | Dysregulated host response to infection, which cause life-threatening organ dysfunction, was defined as sepsis. Sepsis can cause acute and long-term brain dysfunction, namely, sepsis-associated encephalopathy (SAE) and cognitive impairment. SAE refers to changes in consciousness without direct evidence of central nervous system infection. It is highly prevalent and may cause poor outcomes in sepsis patients. Cognitive impairment seriously affects the life quality of sepsis patients and increases the medical burden. The pathogenesis of sepsis-induced brain dysfunction is mainly characterized by the interaction of systemic inflammation, blood-brain barrier (BBB) dysfunction, neuroinflammation, microcirculation dysfunction, and brain dysfunction. Currently, the diagnosis of sepsis-induced brain dysfunction is based on clinical manifestation of altered consciousness along with neuropathological examination, and the treatment is mainly involves controlling sepsis. Although treatments for sepsis-induced brain dysfunction have been tested in animals, clinical treat sepsis-induced brain dysfunction is still difficult. Therefore, we review the underlying mechanisms of sepsis-induced brain injury, which mainly focus on the influence of systemic inflammation on BBB, neuroinflammation, brain microcirculation, and the brain function, which want to bring new mechanism-based directions for future basic and clinical research aimed at preventing or ameliorating brain dysfunction. |
format | Online Article Text |
id | pubmed-9433216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94332162022-09-01 Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment Pan, Shangwen Lv, Zheng Wang, Rui Shu, Huaqing Yuan, Shiying Yu, Yuan Shang, You Oxid Med Cell Longev Review Article Dysregulated host response to infection, which cause life-threatening organ dysfunction, was defined as sepsis. Sepsis can cause acute and long-term brain dysfunction, namely, sepsis-associated encephalopathy (SAE) and cognitive impairment. SAE refers to changes in consciousness without direct evidence of central nervous system infection. It is highly prevalent and may cause poor outcomes in sepsis patients. Cognitive impairment seriously affects the life quality of sepsis patients and increases the medical burden. The pathogenesis of sepsis-induced brain dysfunction is mainly characterized by the interaction of systemic inflammation, blood-brain barrier (BBB) dysfunction, neuroinflammation, microcirculation dysfunction, and brain dysfunction. Currently, the diagnosis of sepsis-induced brain dysfunction is based on clinical manifestation of altered consciousness along with neuropathological examination, and the treatment is mainly involves controlling sepsis. Although treatments for sepsis-induced brain dysfunction have been tested in animals, clinical treat sepsis-induced brain dysfunction is still difficult. Therefore, we review the underlying mechanisms of sepsis-induced brain injury, which mainly focus on the influence of systemic inflammation on BBB, neuroinflammation, brain microcirculation, and the brain function, which want to bring new mechanism-based directions for future basic and clinical research aimed at preventing or ameliorating brain dysfunction. Hindawi 2022-08-24 /pmc/articles/PMC9433216/ /pubmed/36062193 http://dx.doi.org/10.1155/2022/1328729 Text en Copyright © 2022 Shangwen Pan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pan, Shangwen Lv, Zheng Wang, Rui Shu, Huaqing Yuan, Shiying Yu, Yuan Shang, You Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment |
title | Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment |
title_full | Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment |
title_fullStr | Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment |
title_full_unstemmed | Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment |
title_short | Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment |
title_sort | sepsis-induced brain dysfunction: pathogenesis, diagnosis, and treatment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433216/ https://www.ncbi.nlm.nih.gov/pubmed/36062193 http://dx.doi.org/10.1155/2022/1328729 |
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