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Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment

Dysregulated host response to infection, which cause life-threatening organ dysfunction, was defined as sepsis. Sepsis can cause acute and long-term brain dysfunction, namely, sepsis-associated encephalopathy (SAE) and cognitive impairment. SAE refers to changes in consciousness without direct evide...

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Autores principales: Pan, Shangwen, Lv, Zheng, Wang, Rui, Shu, Huaqing, Yuan, Shiying, Yu, Yuan, Shang, You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433216/
https://www.ncbi.nlm.nih.gov/pubmed/36062193
http://dx.doi.org/10.1155/2022/1328729
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author Pan, Shangwen
Lv, Zheng
Wang, Rui
Shu, Huaqing
Yuan, Shiying
Yu, Yuan
Shang, You
author_facet Pan, Shangwen
Lv, Zheng
Wang, Rui
Shu, Huaqing
Yuan, Shiying
Yu, Yuan
Shang, You
author_sort Pan, Shangwen
collection PubMed
description Dysregulated host response to infection, which cause life-threatening organ dysfunction, was defined as sepsis. Sepsis can cause acute and long-term brain dysfunction, namely, sepsis-associated encephalopathy (SAE) and cognitive impairment. SAE refers to changes in consciousness without direct evidence of central nervous system infection. It is highly prevalent and may cause poor outcomes in sepsis patients. Cognitive impairment seriously affects the life quality of sepsis patients and increases the medical burden. The pathogenesis of sepsis-induced brain dysfunction is mainly characterized by the interaction of systemic inflammation, blood-brain barrier (BBB) dysfunction, neuroinflammation, microcirculation dysfunction, and brain dysfunction. Currently, the diagnosis of sepsis-induced brain dysfunction is based on clinical manifestation of altered consciousness along with neuropathological examination, and the treatment is mainly involves controlling sepsis. Although treatments for sepsis-induced brain dysfunction have been tested in animals, clinical treat sepsis-induced brain dysfunction is still difficult. Therefore, we review the underlying mechanisms of sepsis-induced brain injury, which mainly focus on the influence of systemic inflammation on BBB, neuroinflammation, brain microcirculation, and the brain function, which want to bring new mechanism-based directions for future basic and clinical research aimed at preventing or ameliorating brain dysfunction.
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spelling pubmed-94332162022-09-01 Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment Pan, Shangwen Lv, Zheng Wang, Rui Shu, Huaqing Yuan, Shiying Yu, Yuan Shang, You Oxid Med Cell Longev Review Article Dysregulated host response to infection, which cause life-threatening organ dysfunction, was defined as sepsis. Sepsis can cause acute and long-term brain dysfunction, namely, sepsis-associated encephalopathy (SAE) and cognitive impairment. SAE refers to changes in consciousness without direct evidence of central nervous system infection. It is highly prevalent and may cause poor outcomes in sepsis patients. Cognitive impairment seriously affects the life quality of sepsis patients and increases the medical burden. The pathogenesis of sepsis-induced brain dysfunction is mainly characterized by the interaction of systemic inflammation, blood-brain barrier (BBB) dysfunction, neuroinflammation, microcirculation dysfunction, and brain dysfunction. Currently, the diagnosis of sepsis-induced brain dysfunction is based on clinical manifestation of altered consciousness along with neuropathological examination, and the treatment is mainly involves controlling sepsis. Although treatments for sepsis-induced brain dysfunction have been tested in animals, clinical treat sepsis-induced brain dysfunction is still difficult. Therefore, we review the underlying mechanisms of sepsis-induced brain injury, which mainly focus on the influence of systemic inflammation on BBB, neuroinflammation, brain microcirculation, and the brain function, which want to bring new mechanism-based directions for future basic and clinical research aimed at preventing or ameliorating brain dysfunction. Hindawi 2022-08-24 /pmc/articles/PMC9433216/ /pubmed/36062193 http://dx.doi.org/10.1155/2022/1328729 Text en Copyright © 2022 Shangwen Pan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pan, Shangwen
Lv, Zheng
Wang, Rui
Shu, Huaqing
Yuan, Shiying
Yu, Yuan
Shang, You
Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
title Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
title_full Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
title_fullStr Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
title_full_unstemmed Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
title_short Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment
title_sort sepsis-induced brain dysfunction: pathogenesis, diagnosis, and treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433216/
https://www.ncbi.nlm.nih.gov/pubmed/36062193
http://dx.doi.org/10.1155/2022/1328729
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