RASA2 ablation in T cells boosts antigen sensitivity and long-term function

The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive signals from both extrinsic factors and intrinsic inhibitory checkpoints(1,2). Targeted gene editing has the potential to overcome these limitations and enhance T cell therapeutic function(3–10). Here we per...

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Detalles Bibliográficos
Autores principales: Carnevale, Julia, Shifrut, Eric, Kale, Nupura, Nyberg, William A., Blaeschke, Franziska, Chen, Yan Yi, Li, Zhongmei, Bapat, Sagar P., Diolaiti, Morgan E., O’Leary, Patrick, Vedova, Shane, Belk, Julia, Daniel, Bence, Roth, Theodore L., Bachl, Stefanie, Anido, Alejandro Allo, Prinzing, Brooke, Ibañez-Vega, Jorge, Lange, Shannon, Haydar, Dalia, Luetke-Eversloh, Marie, Born-Bony, Maelys, Hegde, Bindu, Kogan, Scott, Feuchtinger, Tobias, Okada, Hideho, Satpathy, Ansuman T., Shannon, Kevin, Gottschalk, Stephen, Eyquem, Justin, Krenciute, Giedre, Ashworth, Alan, Marson, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433322/
https://www.ncbi.nlm.nih.gov/pubmed/36002574
http://dx.doi.org/10.1038/s41586-022-05126-w

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