Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P

Binding of precursor tRNAs (ptRNAs) by bacterial ribonuclease P (RNase P) involves an encounter complex (ES) that isomerizes to a catalytic conformation (ES*). However, the structures of intermediates and the conformational changes that occur during binding are poorly understood. Here, we show that...

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Detalles Bibliográficos
Autores principales: Zhu, Jiaqiang, Huang, Wei, Zhao, Jing, Huynh, Loc, Taylor, Derek J., Harris, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433436/
https://www.ncbi.nlm.nih.gov/pubmed/36045135
http://dx.doi.org/10.1038/s41467-022-32843-7

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