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The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration
High-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but the underlying mechanisms and involved proteins are unknown. Here, we selected 90 copper-related proteins and verified their expression di...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433562/ https://www.ncbi.nlm.nih.gov/pubmed/36060273 http://dx.doi.org/10.3389/fncel.2022.944682 |
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author | Wang, Xu Han, Mingzhi Chen, Songyu Sun, Yanfei Tan, Ruirong Huang, Bin |
author_facet | Wang, Xu Han, Mingzhi Chen, Songyu Sun, Yanfei Tan, Ruirong Huang, Bin |
author_sort | Wang, Xu |
collection | PubMed |
description | High-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but the underlying mechanisms and involved proteins are unknown. Here, we selected 90 copper-related proteins and verified their expression differences in glioma and normal tissues in the TCGA cohort followed by GO and KEGG clustering analyses. We then developed and validated a prognostic model. Moreover, we examined the mutation burden of copper-related proteins and discussed the differences in the immune microenvironment in the high- and low-risk groups. Furthermore, we focused on STEAP2 and demonstrated that STEAP2 expression was relatively low in tumor tissues compared to normal tissues, implying a favorable prognosis. Our findings provide a foundation for future research targeting copper-related proteins and their immune microenvironment to improve prognosis and responses to immunotherapy. |
format | Online Article Text |
id | pubmed-9433562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94335622022-09-02 The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration Wang, Xu Han, Mingzhi Chen, Songyu Sun, Yanfei Tan, Ruirong Huang, Bin Front Cell Neurosci Cellular Neuroscience High-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but the underlying mechanisms and involved proteins are unknown. Here, we selected 90 copper-related proteins and verified their expression differences in glioma and normal tissues in the TCGA cohort followed by GO and KEGG clustering analyses. We then developed and validated a prognostic model. Moreover, we examined the mutation burden of copper-related proteins and discussed the differences in the immune microenvironment in the high- and low-risk groups. Furthermore, we focused on STEAP2 and demonstrated that STEAP2 expression was relatively low in tumor tissues compared to normal tissues, implying a favorable prognosis. Our findings provide a foundation for future research targeting copper-related proteins and their immune microenvironment to improve prognosis and responses to immunotherapy. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9433562/ /pubmed/36060273 http://dx.doi.org/10.3389/fncel.2022.944682 Text en Copyright © 2022 Wang, Han, Chen, Sun, Tan and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Wang, Xu Han, Mingzhi Chen, Songyu Sun, Yanfei Tan, Ruirong Huang, Bin The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
title | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
title_full | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
title_fullStr | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
title_full_unstemmed | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
title_short | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
title_sort | copper-associated protein steap2 correlated with glioma prognosis and immune infiltration |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433562/ https://www.ncbi.nlm.nih.gov/pubmed/36060273 http://dx.doi.org/10.3389/fncel.2022.944682 |
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