Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma

Dysfunctional complement activation and Toll-like receptor signaling immediately after trauma are associated with development of trauma-induced coagulopathy and multiple organ dysfunction syndrome. We assessed the efficacy of the combined inhibition therapy of complement factor C5 and the TLR co-rec...

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Detalles Bibliográficos
Autores principales: Lupu, Ludmila, Horst, Klemens, Greven, Johannes, Mert, Ümit, Ludviksen, Judith A.K., Pettersen, Kristin, Lau, Corinna, Li, Yang, Palmer, Annette, Qin, Kang, Zhang, Xing, Mayer, Benjamin, van Griensven, Martijn, Huber-Lang, Markus, Hildebrand, Frank, Mollnes, Tom Eirik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433645/
https://www.ncbi.nlm.nih.gov/pubmed/36059503
http://dx.doi.org/10.3389/fimmu.2022.952267

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