Ablation of cardiomyocyte-derived BDNF during development causes myocardial degeneration and heart failure in the adult mouse heart

OBJECTIVE: Brain-derived neurotrophic factor (BDNF) and its receptor TrkB-T1 were recently found to be expressed in cardiomyocytes. However, the functional role of cardiomyocyte-derived BDNF in heart pathophysiology is not yet fully known. Recent studies revealed that BDNF-TrkB pathway plays a criti...

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Detalles Bibliográficos
Autores principales: Li, Lilin, Guo, Hongyan, Lai, Binglin, Liang, Chunbao, Chen, Hongyi, Chen, Yilin, Guo, Weimin, Yuan, Ziqiang, Huang, Ruijin, Zeng, Zhaohua, Liang, Liying, Zhao, Hui, Zheng, Xin, Li, Yanmei, Pu, Qin, Qi, Xufeng, Cai, Dongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433718/
https://www.ncbi.nlm.nih.gov/pubmed/36061561
http://dx.doi.org/10.3389/fcvm.2022.967463

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