Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

Cardiomyopathy is a primary cause of death in Friedreich ataxia (FRDA) patients with defective iron-sulfur cluster (ISC) biogenesis due to loss of functional frataxin and in rare patients with functional loss of other ISC biogenesis factors. The mechanistic target of rapamycin (mTOR) and AKT signali...

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Detalles Bibliográficos
Autores principales: Tong, Wing-Hang, Ollivierre, Hayden, Noguchi, Audrey, Ghosh, Manik C., Springer, Danielle A., Rouault, Tracey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433723/
https://www.ncbi.nlm.nih.gov/pubmed/36061025
http://dx.doi.org/10.1016/j.heliyon.2022.e10371

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