Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease

Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset, progressive motor neurodegenerative disorder. A key pathological feature of the disease is the presence of heavily ubiquitinated protein inclusions. Both the unfolded protein response and the ubiquitin–proteasome system appear significantly...

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Detalles Bibliográficos
Autores principales: Tendulkar, Shweta, Hegde, Sushmitha, Garg, Lovleen, Thulasidharan, Aparna, Kaduskar, Bhagyashree, Ratnaparkhi, Anuradha, Ratnaparkhi, Girish S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433731/
https://www.ncbi.nlm.nih.gov/pubmed/35377453
http://dx.doi.org/10.1093/hmg/ddac076

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