Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway

Parkinson’s disease is characterized by the deposition of α-synuclein, which leads to synaptic dysfunction, the loss of neuronal connections and ultimately progressive neurodegeneration. Despite extensive research into Parkinson’s disease pathogenesis, the mechanisms underlying α-synuclein-mediated...

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Detalles Bibliográficos
Autores principales: Parsons, Richard B, Kocinaj, Altin, Ruiz Pulido, Gustavo, Prendergast, Sarah A, Parsons, Anna E, Facey, Paul D, Hirth, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433734/
https://www.ncbi.nlm.nih.gov/pubmed/35397003
http://dx.doi.org/10.1093/hmg/ddac077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433734/
https://www.ncbi.nlm.nih.gov/pubmed/35397003
http://dx.doi.org/10.1093/hmg/ddac077

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