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Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis

BACKGROUND: Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations be...

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Autores principales: Zhang, Yu-Xin, Yang, Lu-Ping, Gai, Cong, Cheng, Cui-Cui, Guo, Zhen-yu, Sun, Hong-Mei, Hu, Die
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433753/
https://www.ncbi.nlm.nih.gov/pubmed/36061291
http://dx.doi.org/10.3389/fpsyt.2022.976428
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author Zhang, Yu-Xin
Yang, Lu-Ping
Gai, Cong
Cheng, Cui-Cui
Guo, Zhen-yu
Sun, Hong-Mei
Hu, Die
author_facet Zhang, Yu-Xin
Yang, Lu-Ping
Gai, Cong
Cheng, Cui-Cui
Guo, Zhen-yu
Sun, Hong-Mei
Hu, Die
author_sort Zhang, Yu-Xin
collection PubMed
description BACKGROUND: Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations between two prevalent MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T, A1298C, severe psychological disorders (schizophrenia, major depression, bipolar disorder). METHODS: A total of 81 published studies were screened and selected by a search of electronic databases up to April 2022. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR polymorphism and psychiatric disorders susceptibility by using random effect models. RESULTS: We found that MTHFR C677T polymorphism is significantly related to schizophrenia and major depression in the overall population. MTHFR C677T has been linked to an increased risk of bipolar disorder in the recessive model (TT vs. CT + CC). Ethnic subgroup analysis shows that schizophrenia and major depression significantly correlate with MTHFR C677T and A1298C in Asian populations but not Caucasians. Besides, schizophrenia is correlated substantially with MTHFR C677T in the African population. However, the MTHFR A1298C polymorphism is only marginally linked to major depression. CONCLUSION: Findings of the current study revealed that MTHFR may contribute to the common pathogenesis of psychiatric diseases and that its variants may be essential in controlling the expression of psychosis-related genes. This study could help the researchers and health specialists in the early diagnosis and treatment of psychiatric disorders.
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spelling pubmed-94337532022-09-02 Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis Zhang, Yu-Xin Yang, Lu-Ping Gai, Cong Cheng, Cui-Cui Guo, Zhen-yu Sun, Hong-Mei Hu, Die Front Psychiatry Psychiatry BACKGROUND: Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations between two prevalent MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T, A1298C, severe psychological disorders (schizophrenia, major depression, bipolar disorder). METHODS: A total of 81 published studies were screened and selected by a search of electronic databases up to April 2022. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR polymorphism and psychiatric disorders susceptibility by using random effect models. RESULTS: We found that MTHFR C677T polymorphism is significantly related to schizophrenia and major depression in the overall population. MTHFR C677T has been linked to an increased risk of bipolar disorder in the recessive model (TT vs. CT + CC). Ethnic subgroup analysis shows that schizophrenia and major depression significantly correlate with MTHFR C677T and A1298C in Asian populations but not Caucasians. Besides, schizophrenia is correlated substantially with MTHFR C677T in the African population. However, the MTHFR A1298C polymorphism is only marginally linked to major depression. CONCLUSION: Findings of the current study revealed that MTHFR may contribute to the common pathogenesis of psychiatric diseases and that its variants may be essential in controlling the expression of psychosis-related genes. This study could help the researchers and health specialists in the early diagnosis and treatment of psychiatric disorders. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9433753/ /pubmed/36061291 http://dx.doi.org/10.3389/fpsyt.2022.976428 Text en Copyright © 2022 Zhang, Yang, Gai, Cheng, Guo, Sun and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zhang, Yu-Xin
Yang, Lu-Ping
Gai, Cong
Cheng, Cui-Cui
Guo, Zhen-yu
Sun, Hong-Mei
Hu, Die
Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
title Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
title_full Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
title_fullStr Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
title_full_unstemmed Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
title_short Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
title_sort association between variants of mthfr genes and psychiatric disorders: a meta-analysis
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433753/
https://www.ncbi.nlm.nih.gov/pubmed/36061291
http://dx.doi.org/10.3389/fpsyt.2022.976428
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