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Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
BACKGROUND: Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations be...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433753/ https://www.ncbi.nlm.nih.gov/pubmed/36061291 http://dx.doi.org/10.3389/fpsyt.2022.976428 |
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author | Zhang, Yu-Xin Yang, Lu-Ping Gai, Cong Cheng, Cui-Cui Guo, Zhen-yu Sun, Hong-Mei Hu, Die |
author_facet | Zhang, Yu-Xin Yang, Lu-Ping Gai, Cong Cheng, Cui-Cui Guo, Zhen-yu Sun, Hong-Mei Hu, Die |
author_sort | Zhang, Yu-Xin |
collection | PubMed |
description | BACKGROUND: Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations between two prevalent MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T, A1298C, severe psychological disorders (schizophrenia, major depression, bipolar disorder). METHODS: A total of 81 published studies were screened and selected by a search of electronic databases up to April 2022. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR polymorphism and psychiatric disorders susceptibility by using random effect models. RESULTS: We found that MTHFR C677T polymorphism is significantly related to schizophrenia and major depression in the overall population. MTHFR C677T has been linked to an increased risk of bipolar disorder in the recessive model (TT vs. CT + CC). Ethnic subgroup analysis shows that schizophrenia and major depression significantly correlate with MTHFR C677T and A1298C in Asian populations but not Caucasians. Besides, schizophrenia is correlated substantially with MTHFR C677T in the African population. However, the MTHFR A1298C polymorphism is only marginally linked to major depression. CONCLUSION: Findings of the current study revealed that MTHFR may contribute to the common pathogenesis of psychiatric diseases and that its variants may be essential in controlling the expression of psychosis-related genes. This study could help the researchers and health specialists in the early diagnosis and treatment of psychiatric disorders. |
format | Online Article Text |
id | pubmed-9433753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94337532022-09-02 Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis Zhang, Yu-Xin Yang, Lu-Ping Gai, Cong Cheng, Cui-Cui Guo, Zhen-yu Sun, Hong-Mei Hu, Die Front Psychiatry Psychiatry BACKGROUND: Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations between two prevalent MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T, A1298C, severe psychological disorders (schizophrenia, major depression, bipolar disorder). METHODS: A total of 81 published studies were screened and selected by a search of electronic databases up to April 2022. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR polymorphism and psychiatric disorders susceptibility by using random effect models. RESULTS: We found that MTHFR C677T polymorphism is significantly related to schizophrenia and major depression in the overall population. MTHFR C677T has been linked to an increased risk of bipolar disorder in the recessive model (TT vs. CT + CC). Ethnic subgroup analysis shows that schizophrenia and major depression significantly correlate with MTHFR C677T and A1298C in Asian populations but not Caucasians. Besides, schizophrenia is correlated substantially with MTHFR C677T in the African population. However, the MTHFR A1298C polymorphism is only marginally linked to major depression. CONCLUSION: Findings of the current study revealed that MTHFR may contribute to the common pathogenesis of psychiatric diseases and that its variants may be essential in controlling the expression of psychosis-related genes. This study could help the researchers and health specialists in the early diagnosis and treatment of psychiatric disorders. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9433753/ /pubmed/36061291 http://dx.doi.org/10.3389/fpsyt.2022.976428 Text en Copyright © 2022 Zhang, Yang, Gai, Cheng, Guo, Sun and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zhang, Yu-Xin Yang, Lu-Ping Gai, Cong Cheng, Cui-Cui Guo, Zhen-yu Sun, Hong-Mei Hu, Die Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis |
title | Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis |
title_full | Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis |
title_fullStr | Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis |
title_full_unstemmed | Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis |
title_short | Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis |
title_sort | association between variants of mthfr genes and psychiatric disorders: a meta-analysis |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433753/ https://www.ncbi.nlm.nih.gov/pubmed/36061291 http://dx.doi.org/10.3389/fpsyt.2022.976428 |
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