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Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer

Purpose: This study investigated the impact of skeletal muscle quality on the outcomes of patients undergoing surgery for early-stage non–small-cell lung cancer (NSCLC). Methods: A total of 98 patients with pathological stage I–II NSCLC who underwent lobectomy or segmentectomy were retrospectively a...

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Autores principales: Kamigaichi, Atsushi, Harada, Hiroaki, Shibata, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433886/
https://www.ncbi.nlm.nih.gov/pubmed/35296583
http://dx.doi.org/10.5761/atcs.oa.21-00274
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author Kamigaichi, Atsushi
Harada, Hiroaki
Shibata, Satoshi
author_facet Kamigaichi, Atsushi
Harada, Hiroaki
Shibata, Satoshi
author_sort Kamigaichi, Atsushi
collection PubMed
description Purpose: This study investigated the impact of skeletal muscle quality on the outcomes of patients undergoing surgery for early-stage non–small-cell lung cancer (NSCLC). Methods: A total of 98 patients with pathological stage I–II NSCLC who underwent lobectomy or segmentectomy were retrospectively analyzed. Along with skeletal muscle quantity, muscle quality was evaluated by intramuscular adipose tissue content (IMAC) at the first lumbar vertebral level; a higher IMAC indicates lower skeletal muscle quality. Patients were divided into two groups according to the gender-specific quartiles of IMAC, and the prognostic impact of IMAC was investigated. Results: No significant differences in the body and skeletal mass indices, which indicate skeletal muscle quantity, were observed between patients with high and those with normal IMAC. Patients with high IMAC (n = 23) showed a significantly poorer prognosis in overall and disease-specific survivals than those with normal IMAC (n = 75; P <0.001 and P = 0.048, respectively). In a bivariate analysis that included other clinicopathological factors, a high IMAC was independently associated with worse overall survival. Conclusion: The skeletal muscle quality evaluated by IMAC could be used to predict survival risk after surgery for early-stage NSCLC.
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spelling pubmed-94338862022-09-15 Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer Kamigaichi, Atsushi Harada, Hiroaki Shibata, Satoshi Ann Thorac Cardiovasc Surg Original Article Purpose: This study investigated the impact of skeletal muscle quality on the outcomes of patients undergoing surgery for early-stage non–small-cell lung cancer (NSCLC). Methods: A total of 98 patients with pathological stage I–II NSCLC who underwent lobectomy or segmentectomy were retrospectively analyzed. Along with skeletal muscle quantity, muscle quality was evaluated by intramuscular adipose tissue content (IMAC) at the first lumbar vertebral level; a higher IMAC indicates lower skeletal muscle quality. Patients were divided into two groups according to the gender-specific quartiles of IMAC, and the prognostic impact of IMAC was investigated. Results: No significant differences in the body and skeletal mass indices, which indicate skeletal muscle quantity, were observed between patients with high and those with normal IMAC. Patients with high IMAC (n = 23) showed a significantly poorer prognosis in overall and disease-specific survivals than those with normal IMAC (n = 75; P <0.001 and P = 0.048, respectively). In a bivariate analysis that included other clinicopathological factors, a high IMAC was independently associated with worse overall survival. Conclusion: The skeletal muscle quality evaluated by IMAC could be used to predict survival risk after surgery for early-stage NSCLC. The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2022-03-16 2022 /pmc/articles/PMC9433886/ /pubmed/35296583 http://dx.doi.org/10.5761/atcs.oa.21-00274 Text en ©2022 Annals of Thoracic and Cardiovascular Surgery https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NonDerivatives International License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Article
Kamigaichi, Atsushi
Harada, Hiroaki
Shibata, Satoshi
Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer
title Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer
title_full Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer
title_fullStr Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer
title_full_unstemmed Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer
title_short Muscle Quality Predicts Outcomes after Surgery for Early-Stage Non–Small-Cell Lung Cancer
title_sort muscle quality predicts outcomes after surgery for early-stage non–small-cell lung cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433886/
https://www.ncbi.nlm.nih.gov/pubmed/35296583
http://dx.doi.org/10.5761/atcs.oa.21-00274
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