Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

PURPOSE: Genomic instability is a hallmark of cancer and targeting DNA damage response (DDR) is emerging as a promising therapeutic strategy in different solid tumors. The effectiveness of targeting DDR in colorectal cancer has not been extensively explored. EXPERIMENTAL DESIGN: We challenged 112 ce...

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Detalles Bibliográficos
Autores principales: Durinikova, Erika, Reilly, Nicole M., Buzo, Kristi, Mariella, Elisa, Chilà, Rosaria, Lorenzato, Annalisa, Dias, João M. L., Grasso, Gaia, Pisati, Federica, Lamba, Simona, Corti, Giorgio, Degasperi, Andrea, Cancelliere, Carlotta, Mauri, Gianluca, Andrei, Pietro, Linnebacher, Michael, Marsoni, Silvia, Siena, Salvatore, Sartore-Bianchi, Andrea, Nik-Zainal, Serena, Di Nicolantonio, Federica, Bardelli, Alberto, Arena, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433963/
https://www.ncbi.nlm.nih.gov/pubmed/35881546
http://dx.doi.org/10.1158/1078-0432.CCR-22-0875

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