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Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis

BACKGROUND: Motor fatigue is common in multiple sclerosis (MS), but its pathophysiology is still poorly understood. Here we used functional magnetic resonance imaging (fMRI) to delineate how the acute induction of motor fatigue alters functional activity of the motor system and how these activity ch...

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Autores principales: Svolgaard, Olivia, Winther Andersen, Kasper, Bauer, Christian, Hougaard Madsen, Kristoffer, Blinkenberg, Morten, Sellebjerg, Finn, Roman Siebner, Hartwig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434128/
https://www.ncbi.nlm.nih.gov/pubmed/36030719
http://dx.doi.org/10.1016/j.nicl.2022.103147
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author Svolgaard, Olivia
Winther Andersen, Kasper
Bauer, Christian
Hougaard Madsen, Kristoffer
Blinkenberg, Morten
Sellebjerg, Finn
Roman Siebner, Hartwig
author_facet Svolgaard, Olivia
Winther Andersen, Kasper
Bauer, Christian
Hougaard Madsen, Kristoffer
Blinkenberg, Morten
Sellebjerg, Finn
Roman Siebner, Hartwig
author_sort Svolgaard, Olivia
collection PubMed
description BACKGROUND: Motor fatigue is common in multiple sclerosis (MS), but its pathophysiology is still poorly understood. Here we used functional magnetic resonance imaging (fMRI) to delineate how the acute induction of motor fatigue alters functional activity of the motor system and how these activity changes are related to motor fatigue. METHOD: Forty-four right-handed mildly disabled patients with relapsing-remitting MS and 25 healthy controls performed a maximal tonic precision grip with their right hand until they developed motor fatigue. Before and after the fatiguing task, participants performed a non-fatiguing tonic grip force task, producing 15–20% of their maximum grip force based on visual feedback. Task related brain activity was mapped with blood-oxygen level dependent fMRI at 3 T. Statistical parametric mapping was used to identify relative changes in task-related activation from the pre-fatigue to the recovery MRI session. RESULTS: Following fatigue induction, task performance was perturbed in both groups, and task-related activation increased in the right (ipsilateral) primary motor hand area. In patients with MS, task-related activity increased bilaterally during the recovery phase in the ventrolateral portion of the middle putamen and lateral prefrontal cortex relative to controls. The more patients increased task-related activity in left dorsal premotor cortex after the fatiguing task, the less they experienced motor fatigue during daily life. CONCLUSION: Patients with MS show enhanced functional engagement of the associative cortico-basal ganglia loop following acute induction of motor fatigue in the contralateral hand. This may reflect increased mental effort to generate movements in the recovery phase after fatigue induction. The ability to recruit the contralateral dorsal premotor cortex after fatigue induction may constitute a protective mechanism against experiencing motor fatigue in everyday life.
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spelling pubmed-94341282022-09-02 Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis Svolgaard, Olivia Winther Andersen, Kasper Bauer, Christian Hougaard Madsen, Kristoffer Blinkenberg, Morten Sellebjerg, Finn Roman Siebner, Hartwig Neuroimage Clin Regular Article BACKGROUND: Motor fatigue is common in multiple sclerosis (MS), but its pathophysiology is still poorly understood. Here we used functional magnetic resonance imaging (fMRI) to delineate how the acute induction of motor fatigue alters functional activity of the motor system and how these activity changes are related to motor fatigue. METHOD: Forty-four right-handed mildly disabled patients with relapsing-remitting MS and 25 healthy controls performed a maximal tonic precision grip with their right hand until they developed motor fatigue. Before and after the fatiguing task, participants performed a non-fatiguing tonic grip force task, producing 15–20% of their maximum grip force based on visual feedback. Task related brain activity was mapped with blood-oxygen level dependent fMRI at 3 T. Statistical parametric mapping was used to identify relative changes in task-related activation from the pre-fatigue to the recovery MRI session. RESULTS: Following fatigue induction, task performance was perturbed in both groups, and task-related activation increased in the right (ipsilateral) primary motor hand area. In patients with MS, task-related activity increased bilaterally during the recovery phase in the ventrolateral portion of the middle putamen and lateral prefrontal cortex relative to controls. The more patients increased task-related activity in left dorsal premotor cortex after the fatiguing task, the less they experienced motor fatigue during daily life. CONCLUSION: Patients with MS show enhanced functional engagement of the associative cortico-basal ganglia loop following acute induction of motor fatigue in the contralateral hand. This may reflect increased mental effort to generate movements in the recovery phase after fatigue induction. The ability to recruit the contralateral dorsal premotor cortex after fatigue induction may constitute a protective mechanism against experiencing motor fatigue in everyday life. Elsevier 2022-08-06 /pmc/articles/PMC9434128/ /pubmed/36030719 http://dx.doi.org/10.1016/j.nicl.2022.103147 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Svolgaard, Olivia
Winther Andersen, Kasper
Bauer, Christian
Hougaard Madsen, Kristoffer
Blinkenberg, Morten
Sellebjerg, Finn
Roman Siebner, Hartwig
Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis
title Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis
title_full Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis
title_fullStr Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis
title_full_unstemmed Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis
title_short Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis
title_sort mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434128/
https://www.ncbi.nlm.nih.gov/pubmed/36030719
http://dx.doi.org/10.1016/j.nicl.2022.103147
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