Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus

Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancr...

Descripción completa

Detalles Bibliográficos
Autores principales: You, SuFang, Zheng, JingYi, Chen, YuPing, Huang, HuiBin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434279/
https://www.ncbi.nlm.nih.gov/pubmed/36060972
http://dx.doi.org/10.3389/fendo.2022.976465
_version_ 1784780832545701888
author You, SuFang
Zheng, JingYi
Chen, YuPing
Huang, HuiBin
author_facet You, SuFang
Zheng, JingYi
Chen, YuPing
Huang, HuiBin
author_sort You, SuFang
collection PubMed
description Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancreatic beta-cell function in T2DM can be attributable to beta-cell apoptosis, but the exact mechanisms of beta-cell apoptosis in T2DM are not yet fully clarified. Therefore, in this review, we will focus on the current status and progress of research on the mechanism of pancreatic beta-cell apoptosis in T2DM, to provide new ideas for T2DM treatment strategies.
format Online
Article
Text
id pubmed-9434279
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94342792022-09-02 Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus You, SuFang Zheng, JingYi Chen, YuPing Huang, HuiBin Front Endocrinol (Lausanne) Endocrinology Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancreatic beta-cell function in T2DM can be attributable to beta-cell apoptosis, but the exact mechanisms of beta-cell apoptosis in T2DM are not yet fully clarified. Therefore, in this review, we will focus on the current status and progress of research on the mechanism of pancreatic beta-cell apoptosis in T2DM, to provide new ideas for T2DM treatment strategies. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9434279/ /pubmed/36060972 http://dx.doi.org/10.3389/fendo.2022.976465 Text en Copyright © 2022 You, Zheng, Chen and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
You, SuFang
Zheng, JingYi
Chen, YuPing
Huang, HuiBin
Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
title Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
title_full Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
title_fullStr Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
title_full_unstemmed Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
title_short Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
title_sort research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434279/
https://www.ncbi.nlm.nih.gov/pubmed/36060972
http://dx.doi.org/10.3389/fendo.2022.976465
work_keys_str_mv AT yousufang researchprogressonthemechanismofbetacellapoptosisintype2diabetesmellitus
AT zhengjingyi researchprogressonthemechanismofbetacellapoptosisintype2diabetesmellitus
AT chenyuping researchprogressonthemechanismofbetacellapoptosisintype2diabetesmellitus
AT huanghuibin researchprogressonthemechanismofbetacellapoptosisintype2diabetesmellitus

Ejemplares similares