Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is converted into an induced neuron without traversing a pluripotent state, has tremendous therapeutic potential for a host of neurodegenerative diseases. While there is strong evidence for astrocyte-to-neuron conver...

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Detalles Bibliográficos
Autores principales: Ghazale, Hussein, Park, EunJee, Vasan, Lakshmy, Mester, James, Saleh, Fermisk, Trevisiol, Andrea, Zinyk, Dawn, Chinchalongporn, Vorapin, Liu, Mingzhe, Fleming, Taylor, Prokopchuk, Oleksandr, Klenin, Natalia, Kurrasch, Deborah, Faiz, Maryam, Stefanovic, Bojana, McLaurin, JoAnne, Schuurmans, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434350/
https://www.ncbi.nlm.nih.gov/pubmed/36061596
http://dx.doi.org/10.3389/fnins.2022.917071

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