Palladium-catalyzed C–H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues

The palladium-catalyzed oxidative C–H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported herein. This protocol provides an efficient, atom-economic and environmentally friendly approach to the synthesis of biologically important C5-alkene modified uracil/...

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Detalles Bibliográficos
Autores principales: Zhao, Qin, Xie, Ruoqian, Zeng, Yuxiao, Li, Wanlu, Xiao, Guolan, Li, Yangyan, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434382/
https://www.ncbi.nlm.nih.gov/pubmed/36199883
http://dx.doi.org/10.1039/d2ra03681a
Descripción
Sumario:The palladium-catalyzed oxidative C–H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported herein. This protocol provides an efficient, atom-economic and environmentally friendly approach to the synthesis of biologically important C5-alkene modified uracil/uridine-containing derivatives and pharmaceutical candidates.

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