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Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables
BACKGROUND: Obesity is a risk factor for the development of fibromyalgia (FM) and generally most studies report increased Body Mass Index (BMI) in FM. Obesity in FM is associated with a worse clinical presentation. FM patients have low physical conditioning and obesity further exacerbates these aspe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434492/ https://www.ncbi.nlm.nih.gov/pubmed/36061487 http://dx.doi.org/10.2147/JPR.S376590 |
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author | Gerdle, Björn Dahlqvist Leinhard, Olof Lund, Eva Bengtsson, Ann Lundberg, Peter Ghafouri, Bijar Forsgren, Mikael Fredrik |
author_facet | Gerdle, Björn Dahlqvist Leinhard, Olof Lund, Eva Bengtsson, Ann Lundberg, Peter Ghafouri, Bijar Forsgren, Mikael Fredrik |
author_sort | Gerdle, Björn |
collection | PubMed |
description | BACKGROUND: Obesity is a risk factor for the development of fibromyalgia (FM) and generally most studies report increased Body Mass Index (BMI) in FM. Obesity in FM is associated with a worse clinical presentation. FM patients have low physical conditioning and obesity further exacerbates these aspects. Hitherto studies of FM have focused upon a surrogate for overall measure of fat content, ie, BMI. This study is motivated by that ectopic fat and adipose tissues are rarely investigated in FM including their relationships to physical capacity variables. Moreover, their relationships to clinical variables including are not known. Aims were to 1) compare body composition between FM and healthy controls and 2) investigate if significant associations exist between body composition and physical capacity aspects and important clinical variables. METHODS: FM patients (n = 32) and healthy controls (CON; n = 30) underwent a clinical examination that included pressure pain thresholds and physical tests. They completed a health questionnaire and participated in whole-body magnetic resonance imaging (MRI) to determine body composition aspects. RESULTS: Abdominal adipose tissues, muscle fat, and BMI were significantly higher in FM, whereas muscle volumes of quadriceps were smaller. Physical capacity variables correlated negatively with body composition variables in FM. Both body composition and physical capacity variables were significant regressors of group belonging; the physical capacity variables alone showed stronger relationships with group membership. A mix of body composition variables and physical capacity variables were significant regressors of pain intensity and impact in FM. Body composition variables were the strongest regressors of blood pressures, which were increased in FM. CONCLUSION: Obesity has a negative influence on FM symptomatology and increases the risk for other serious conditions. Hence, obesity, dietary habits, and physical activity should be considered when developing clinical management plans for patients with FM. |
format | Online Article Text |
id | pubmed-9434492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-94344922022-09-02 Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables Gerdle, Björn Dahlqvist Leinhard, Olof Lund, Eva Bengtsson, Ann Lundberg, Peter Ghafouri, Bijar Forsgren, Mikael Fredrik J Pain Res Original Research BACKGROUND: Obesity is a risk factor for the development of fibromyalgia (FM) and generally most studies report increased Body Mass Index (BMI) in FM. Obesity in FM is associated with a worse clinical presentation. FM patients have low physical conditioning and obesity further exacerbates these aspects. Hitherto studies of FM have focused upon a surrogate for overall measure of fat content, ie, BMI. This study is motivated by that ectopic fat and adipose tissues are rarely investigated in FM including their relationships to physical capacity variables. Moreover, their relationships to clinical variables including are not known. Aims were to 1) compare body composition between FM and healthy controls and 2) investigate if significant associations exist between body composition and physical capacity aspects and important clinical variables. METHODS: FM patients (n = 32) and healthy controls (CON; n = 30) underwent a clinical examination that included pressure pain thresholds and physical tests. They completed a health questionnaire and participated in whole-body magnetic resonance imaging (MRI) to determine body composition aspects. RESULTS: Abdominal adipose tissues, muscle fat, and BMI were significantly higher in FM, whereas muscle volumes of quadriceps were smaller. Physical capacity variables correlated negatively with body composition variables in FM. Both body composition and physical capacity variables were significant regressors of group belonging; the physical capacity variables alone showed stronger relationships with group membership. A mix of body composition variables and physical capacity variables were significant regressors of pain intensity and impact in FM. Body composition variables were the strongest regressors of blood pressures, which were increased in FM. CONCLUSION: Obesity has a negative influence on FM symptomatology and increases the risk for other serious conditions. Hence, obesity, dietary habits, and physical activity should be considered when developing clinical management plans for patients with FM. Dove 2022-08-27 /pmc/articles/PMC9434492/ /pubmed/36061487 http://dx.doi.org/10.2147/JPR.S376590 Text en © 2022 Gerdle et al. https://creativecommons.org/licenses/by/4.0/This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Research Gerdle, Björn Dahlqvist Leinhard, Olof Lund, Eva Bengtsson, Ann Lundberg, Peter Ghafouri, Bijar Forsgren, Mikael Fredrik Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
title | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
title_full | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
title_fullStr | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
title_full_unstemmed | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
title_short | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
title_sort | fibromyalgia: associations between fat infiltration, physical capacity, and clinical variables |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434492/ https://www.ncbi.nlm.nih.gov/pubmed/36061487 http://dx.doi.org/10.2147/JPR.S376590 |
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