Cargando…

Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus

AIMS/INTRODUCTION: The bone mineral density in patients with type 1 diabetes mellitus is reduced due to impaired insulin secretion. However, it is unclear whether the rate of bone mineral density reduction is affected by the type 1 diabetes mellitus subtype. This study aimed to clarify the differenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Suzuki, Masaki, Urai, Shin, Fukuoka, Hidenori, Hirota, Yushi, Yamamoto, Masaaki, Okada, Yuko, Yamamoto, Naoki, Shichi, Hiroki, Fujita, Yasunori, Kanie, Keitaro, Iguchi, Genzo, Takahashi, Yutaka, Ogawa, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434576/
https://www.ncbi.nlm.nih.gov/pubmed/35470583
http://dx.doi.org/10.1111/jdi.13817
_version_ 1784780903218675712
author Suzuki, Masaki
Urai, Shin
Fukuoka, Hidenori
Hirota, Yushi
Yamamoto, Masaaki
Okada, Yuko
Yamamoto, Naoki
Shichi, Hiroki
Fujita, Yasunori
Kanie, Keitaro
Iguchi, Genzo
Takahashi, Yutaka
Ogawa, Wataru
author_facet Suzuki, Masaki
Urai, Shin
Fukuoka, Hidenori
Hirota, Yushi
Yamamoto, Masaaki
Okada, Yuko
Yamamoto, Naoki
Shichi, Hiroki
Fujita, Yasunori
Kanie, Keitaro
Iguchi, Genzo
Takahashi, Yutaka
Ogawa, Wataru
author_sort Suzuki, Masaki
collection PubMed
description AIMS/INTRODUCTION: The bone mineral density in patients with type 1 diabetes mellitus is reduced due to impaired insulin secretion. However, it is unclear whether the rate of bone mineral density reduction is affected by the type 1 diabetes mellitus subtype. This study aimed to clarify the difference in bone mineral density across type 1 diabetes mellitus subtypes: slowly progressive (SP), acute‐onset (AO), and fulminant (F). METHODS: This was a retrospective, single‐center, cross‐sectional study conducted on 98 adult type 1 diabetes mellitus patients. The main outcome included the bone mineral density Z‐score (BMD‐Z) measured at the lumbar spine and femoral neck. RESULTS: The lumbar spine BMD‐Z was lower in the acute‐onset than in the slowly progressive subtype (P = 0.03). No differences were observed when compared with the fulminant subtype. The femoral neck BMD‐Z tended to be higher in the slowly progressive than in the acute‐onset and fulminant subtypes. Multiple regression analyses showed that the lumbar spine BMD‐Z was associated with subtypes (AO vs SP) (P = 0.01), but not subtypes (F vs SP), adjusted for sex, duration, retinopathy, and C‐peptide immunoreactivity (CPR). When the patients were divided into disease duration tertiles, in the first and second tertiles, the CPR levels were lower in the acute‐onset or fulminant than in the slowly progressive subtype. In contrast, the lumbar spine and femoral neck BMD‐Z differed between the acute‐onset and slowly progressive only in the second tertiles (both P < 0.01), with a similar tendency between the fulminant and slowly progressive subtypes. CONCLUSIONS: Among the type 1 diabetes mellitus subtypes, bone mineral density undergoes time‐dependent changes, which reveals that the bone mineral density decline follows the impaired insulin secretion. These results provide novel insights into the association between the low insulin exposure duration and bone mineral density.
format Online
Article
Text
id pubmed-9434576
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-94345762022-09-08 Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus Suzuki, Masaki Urai, Shin Fukuoka, Hidenori Hirota, Yushi Yamamoto, Masaaki Okada, Yuko Yamamoto, Naoki Shichi, Hiroki Fujita, Yasunori Kanie, Keitaro Iguchi, Genzo Takahashi, Yutaka Ogawa, Wataru J Diabetes Investig Articles AIMS/INTRODUCTION: The bone mineral density in patients with type 1 diabetes mellitus is reduced due to impaired insulin secretion. However, it is unclear whether the rate of bone mineral density reduction is affected by the type 1 diabetes mellitus subtype. This study aimed to clarify the difference in bone mineral density across type 1 diabetes mellitus subtypes: slowly progressive (SP), acute‐onset (AO), and fulminant (F). METHODS: This was a retrospective, single‐center, cross‐sectional study conducted on 98 adult type 1 diabetes mellitus patients. The main outcome included the bone mineral density Z‐score (BMD‐Z) measured at the lumbar spine and femoral neck. RESULTS: The lumbar spine BMD‐Z was lower in the acute‐onset than in the slowly progressive subtype (P = 0.03). No differences were observed when compared with the fulminant subtype. The femoral neck BMD‐Z tended to be higher in the slowly progressive than in the acute‐onset and fulminant subtypes. Multiple regression analyses showed that the lumbar spine BMD‐Z was associated with subtypes (AO vs SP) (P = 0.01), but not subtypes (F vs SP), adjusted for sex, duration, retinopathy, and C‐peptide immunoreactivity (CPR). When the patients were divided into disease duration tertiles, in the first and second tertiles, the CPR levels were lower in the acute‐onset or fulminant than in the slowly progressive subtype. In contrast, the lumbar spine and femoral neck BMD‐Z differed between the acute‐onset and slowly progressive only in the second tertiles (both P < 0.01), with a similar tendency between the fulminant and slowly progressive subtypes. CONCLUSIONS: Among the type 1 diabetes mellitus subtypes, bone mineral density undergoes time‐dependent changes, which reveals that the bone mineral density decline follows the impaired insulin secretion. These results provide novel insights into the association between the low insulin exposure duration and bone mineral density. John Wiley and Sons Inc. 2022-05-31 2022-09 /pmc/articles/PMC9434576/ /pubmed/35470583 http://dx.doi.org/10.1111/jdi.13817 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
Suzuki, Masaki
Urai, Shin
Fukuoka, Hidenori
Hirota, Yushi
Yamamoto, Masaaki
Okada, Yuko
Yamamoto, Naoki
Shichi, Hiroki
Fujita, Yasunori
Kanie, Keitaro
Iguchi, Genzo
Takahashi, Yutaka
Ogawa, Wataru
Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus
title Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus
title_full Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus
title_fullStr Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus
title_full_unstemmed Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus
title_short Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus
title_sort relation between the insulin lowering rate and changes in bone mineral density: analysis among subtypes of type 1 diabetes mellitus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434576/
https://www.ncbi.nlm.nih.gov/pubmed/35470583
http://dx.doi.org/10.1111/jdi.13817
work_keys_str_mv AT suzukimasaki relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT uraishin relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT fukuokahidenori relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT hirotayushi relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT yamamotomasaaki relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT okadayuko relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT yamamotonaoki relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT shichihiroki relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT fujitayasunori relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT kaniekeitaro relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT iguchigenzo relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT takahashiyutaka relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus
AT ogawawataru relationbetweentheinsulinloweringrateandchangesinbonemineraldensityanalysisamongsubtypesoftype1diabetesmellitus