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Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt

Six phenolic compounds (talaroflavone (1), alternarienoic acid (2), altenuene (3), altenusin (4), alternariol (5), and alternariol-5-O-methyl ether (6)) were isolated from the solid rice culture media of Alternaria sp., an endophyte isolated from the fresh leaves of three desert plants, Lycium schwe...

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Autores principales: Elbermawi, Ahmed, Ali, Ahmed R., Amen, Yhiya, Ashour, Ahmed, Ahmad, Kadria F., Mansour, El-Sayed S., Halim, Ahmed F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434606/
https://www.ncbi.nlm.nih.gov/pubmed/36199870
http://dx.doi.org/10.1039/d2ra02532a
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author Elbermawi, Ahmed
Ali, Ahmed R.
Amen, Yhiya
Ashour, Ahmed
Ahmad, Kadria F.
Mansour, El-Sayed S.
Halim, Ahmed F.
author_facet Elbermawi, Ahmed
Ali, Ahmed R.
Amen, Yhiya
Ashour, Ahmed
Ahmad, Kadria F.
Mansour, El-Sayed S.
Halim, Ahmed F.
author_sort Elbermawi, Ahmed
collection PubMed
description Six phenolic compounds (talaroflavone (1), alternarienoic acid (2), altenuene (3), altenusin (4), alternariol (5), and alternariol-5-O-methyl ether (6)) were isolated from the solid rice culture media of Alternaria sp., an endophyte isolated from the fresh leaves of three desert plants, Lycium schweinfurthii Dammer (Solanaceae), Pancratium maritimum L. (Amaryllidaceae) and Cynanchum acutum L. (Apocynaceae). Compounds 2, 3, and 4 exhibited potent α-glucosidase and lipase inhibitory activities suggesting that they might act as naturally occurring anti-diabetic candidates. The same compounds showed potent binding in the active site for both enzymes with desirable pharmacokinetic properties. The isolated bioactive compounds were not exclusive to a certain host plant which reveals the dominant ecological standpoints for consequent optimization. This could lead to a cost-effective and reproducible yield applicable to commercial scale-up.
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spelling pubmed-94346062022-10-04 Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt Elbermawi, Ahmed Ali, Ahmed R. Amen, Yhiya Ashour, Ahmed Ahmad, Kadria F. Mansour, El-Sayed S. Halim, Ahmed F. RSC Adv Chemistry Six phenolic compounds (talaroflavone (1), alternarienoic acid (2), altenuene (3), altenusin (4), alternariol (5), and alternariol-5-O-methyl ether (6)) were isolated from the solid rice culture media of Alternaria sp., an endophyte isolated from the fresh leaves of three desert plants, Lycium schweinfurthii Dammer (Solanaceae), Pancratium maritimum L. (Amaryllidaceae) and Cynanchum acutum L. (Apocynaceae). Compounds 2, 3, and 4 exhibited potent α-glucosidase and lipase inhibitory activities suggesting that they might act as naturally occurring anti-diabetic candidates. The same compounds showed potent binding in the active site for both enzymes with desirable pharmacokinetic properties. The isolated bioactive compounds were not exclusive to a certain host plant which reveals the dominant ecological standpoints for consequent optimization. This could lead to a cost-effective and reproducible yield applicable to commercial scale-up. The Royal Society of Chemistry 2022-09-01 /pmc/articles/PMC9434606/ /pubmed/36199870 http://dx.doi.org/10.1039/d2ra02532a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Elbermawi, Ahmed
Ali, Ahmed R.
Amen, Yhiya
Ashour, Ahmed
Ahmad, Kadria F.
Mansour, El-Sayed S.
Halim, Ahmed F.
Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt
title Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt
title_full Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt
title_fullStr Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt
title_full_unstemmed Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt
title_short Anti-diabetic activities of phenolic compounds of Alternaria sp., an endophyte isolated from the leaves of desert plants growing in Egypt
title_sort anti-diabetic activities of phenolic compounds of alternaria sp., an endophyte isolated from the leaves of desert plants growing in egypt
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434606/
https://www.ncbi.nlm.nih.gov/pubmed/36199870
http://dx.doi.org/10.1039/d2ra02532a
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