Chlorine Atoms of an Aripiprazole Molecule Control the Geometry and Motion of Aripiprazole and Deschloro-aripiprazole in Subdomain IIIA of Human Serum Albumin

[Image: see text] Aripiprazole (ARP), an antipsychotic drug, binds more strongly to human serum albumin (HSA) than the other ARP derivatives. In addition, the signs for the extrinsic Cotton effects for HSA complexed with ARP or deschloro-ARP are reversed. In this study, we report on a structural–che...

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Detalles Bibliográficos
Autores principales: Kawai, Akito, Kobashigawa, Yoshihiro, Hirata, Kenshiro, Morioka, Hiroshi, Imoto, Shuhei, Nishi, Koji, Chuang, Victor Tuan Giam, Yamasaki, Keishi, Otagiri, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434609/
https://www.ncbi.nlm.nih.gov/pubmed/36061730
http://dx.doi.org/10.1021/acsomega.2c02929

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