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Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin
[Image: see text] Oleogels (OGs) have gained a lot of interest as a delivery system for a variety of pharmaceuticals. The current study explains the development of jasmine floral wax (JFW) and wheat germ oil (WGO)-based OGs for oral drug (curcumin) delivery application. The OGs were made by dissolvi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434628/ https://www.ncbi.nlm.nih.gov/pubmed/36061661 http://dx.doi.org/10.1021/acsomega.2c03201 |
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author | Babu, Anashwara Sivakumar, Gomathi Das, Anubhab Bharti, Deepti Qureshi, Dilshad Habibullah, SK Satheesan, Anjana Mohanty, Biswaranjan Pal, Kunal Maji, Samarendra |
author_facet | Babu, Anashwara Sivakumar, Gomathi Das, Anubhab Bharti, Deepti Qureshi, Dilshad Habibullah, SK Satheesan, Anjana Mohanty, Biswaranjan Pal, Kunal Maji, Samarendra |
author_sort | Babu, Anashwara |
collection | PubMed |
description | [Image: see text] Oleogels (OGs) have gained a lot of interest as a delivery system for a variety of pharmaceuticals. The current study explains the development of jasmine floral wax (JFW) and wheat germ oil (WGO)-based OGs for oral drug (curcumin) delivery application. The OGs were made by dissolving JFW in WGO at 70 °C and cooling it to room temperature (25 °C). The critical gelation concentration of JFW that induces the gelation of WGO was found to be 10% (w/w). The OGs were characterized using various techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), microscopic analysis, and mechanical test. XRD data indicated that JFW influences the crystallinity of the OGs. Among the prepared OGs, OG 17.5 showed higher crystallization in the series. Optical microscopic studies demonstrated the formation of fiber structures due to the entanglement of crystals whereas, polarized light micrographs suggested the formation of spherulites or clustered crystallite structures. The mechanical properties of the OGs increased linearly with the increase in the JFW concentration. Curcumin-loaded OGs were examined for their controlled release applications. In summary, the developed OGs were found to have the necessary features for modulating the oral delivery of curcumin. |
format | Online Article Text |
id | pubmed-9434628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94346282022-09-02 Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin Babu, Anashwara Sivakumar, Gomathi Das, Anubhab Bharti, Deepti Qureshi, Dilshad Habibullah, SK Satheesan, Anjana Mohanty, Biswaranjan Pal, Kunal Maji, Samarendra ACS Omega [Image: see text] Oleogels (OGs) have gained a lot of interest as a delivery system for a variety of pharmaceuticals. The current study explains the development of jasmine floral wax (JFW) and wheat germ oil (WGO)-based OGs for oral drug (curcumin) delivery application. The OGs were made by dissolving JFW in WGO at 70 °C and cooling it to room temperature (25 °C). The critical gelation concentration of JFW that induces the gelation of WGO was found to be 10% (w/w). The OGs were characterized using various techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), microscopic analysis, and mechanical test. XRD data indicated that JFW influences the crystallinity of the OGs. Among the prepared OGs, OG 17.5 showed higher crystallization in the series. Optical microscopic studies demonstrated the formation of fiber structures due to the entanglement of crystals whereas, polarized light micrographs suggested the formation of spherulites or clustered crystallite structures. The mechanical properties of the OGs increased linearly with the increase in the JFW concentration. Curcumin-loaded OGs were examined for their controlled release applications. In summary, the developed OGs were found to have the necessary features for modulating the oral delivery of curcumin. American Chemical Society 2022-08-17 /pmc/articles/PMC9434628/ /pubmed/36061661 http://dx.doi.org/10.1021/acsomega.2c03201 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Babu, Anashwara Sivakumar, Gomathi Das, Anubhab Bharti, Deepti Qureshi, Dilshad Habibullah, SK Satheesan, Anjana Mohanty, Biswaranjan Pal, Kunal Maji, Samarendra Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin |
title | Preparation and
Characterization of Novel Oleogels
Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin |
title_full | Preparation and
Characterization of Novel Oleogels
Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin |
title_fullStr | Preparation and
Characterization of Novel Oleogels
Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin |
title_full_unstemmed | Preparation and
Characterization of Novel Oleogels
Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin |
title_short | Preparation and
Characterization of Novel Oleogels
Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin |
title_sort | preparation and
characterization of novel oleogels
using jasmine floral wax and wheat germ oil for oral delivery of curcumin |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434628/ https://www.ncbi.nlm.nih.gov/pubmed/36061661 http://dx.doi.org/10.1021/acsomega.2c03201 |
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