Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost

Immune checkpoint inhibitors are associated with a myriad of autoimmune adverse events. We present a 70-year-old patient with renal-cell carcinoma treated with nivolumab/ipilimumab complicated with myocarditis and encephalitis in which gradual impairment of the His-Purkinje system progressed to comp...

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Autores principales: Lorente-Ros, Álvaro, Rajjoub-Al-Mahdi, Ez-Alddin, Monteagudo Ruiz, Juan M., Rivas García, Sonia, Ortega Pérez, Rodrigo, Fernández Golfín, Covadonga, Álvarez-García, Jesús, Zamorano Gómez, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434642/
https://www.ncbi.nlm.nih.gov/pubmed/36062054
http://dx.doi.org/10.1016/j.jaccas.2022.04.020
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author Lorente-Ros, Álvaro
Rajjoub-Al-Mahdi, Ez-Alddin
Monteagudo Ruiz, Juan M.
Rivas García, Sonia
Ortega Pérez, Rodrigo
Fernández Golfín, Covadonga
Álvarez-García, Jesús
Zamorano Gómez, José L.
author_facet Lorente-Ros, Álvaro
Rajjoub-Al-Mahdi, Ez-Alddin
Monteagudo Ruiz, Juan M.
Rivas García, Sonia
Ortega Pérez, Rodrigo
Fernández Golfín, Covadonga
Álvarez-García, Jesús
Zamorano Gómez, José L.
author_sort Lorente-Ros, Álvaro
collection PubMed
description Immune checkpoint inhibitors are associated with a myriad of autoimmune adverse events. We present a 70-year-old patient with renal-cell carcinoma treated with nivolumab/ipilimumab complicated with myocarditis and encephalitis in which gradual impairment of the His-Purkinje system progressed to complete atrioventricular block. Full recovery was achieved after treatment with corticosteroids and immunoglobulins. (Level of Difficulty: Intermediate.)
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spelling pubmed-94346422022-09-02 Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost Lorente-Ros, Álvaro Rajjoub-Al-Mahdi, Ez-Alddin Monteagudo Ruiz, Juan M. Rivas García, Sonia Ortega Pérez, Rodrigo Fernández Golfín, Covadonga Álvarez-García, Jesús Zamorano Gómez, José L. JACC Case Rep Case Report Immune checkpoint inhibitors are associated with a myriad of autoimmune adverse events. We present a 70-year-old patient with renal-cell carcinoma treated with nivolumab/ipilimumab complicated with myocarditis and encephalitis in which gradual impairment of the His-Purkinje system progressed to complete atrioventricular block. Full recovery was achieved after treatment with corticosteroids and immunoglobulins. (Level of Difficulty: Intermediate.) Elsevier 2022-08-17 /pmc/articles/PMC9434642/ /pubmed/36062054 http://dx.doi.org/10.1016/j.jaccas.2022.04.020 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lorente-Ros, Álvaro
Rajjoub-Al-Mahdi, Ez-Alddin
Monteagudo Ruiz, Juan M.
Rivas García, Sonia
Ortega Pérez, Rodrigo
Fernández Golfín, Covadonga
Álvarez-García, Jesús
Zamorano Gómez, José L.
Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost
title Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost
title_full Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost
title_fullStr Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost
title_full_unstemmed Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost
title_short Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost
title_sort checkpoint immunotherapy-induced myocarditis and encephalitis complicated with complete av block: not all hope is lost
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434642/
https://www.ncbi.nlm.nih.gov/pubmed/36062054
http://dx.doi.org/10.1016/j.jaccas.2022.04.020
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