Core–Shell Polydopamine/Cu Nanometer Rods Efficiently Deactivate Microbes by Mimicking Chloride-Activated Peroxidases

[Image: see text] Cu-modified nanoparticles have been designed to mimic peroxidase, and their potent antibacterial and anti-biofilm abilities have been widely investigated. In this study, novel core–shell polydopamine (PDA)/Cu(4)(OH)(6)SO(4) crystal (PDA/Cu) nanometer rods were prepared. The PDA/Cu nanometer rods show similar kinetic behaviors to chloride-activated peroxidases, exhibit excellent photothermal properties, and are sensitive to the concentrations of pH values and the substrate (i.e., H(2)O(2)). PDA/Cu nanometer rods could adhere to the bacteria and catalyze hydrogen peroxide (H(2)O(2)) to generate more reactive hydroxy radicals ((•)OH) against Staphylococcus aureus and Escherichia coli, Furthermore, PDA/Cu nanometer rods show enhanced catalytic and photothermal synergistic antibacterial activity. This work provides a simple, inexpensive, and effective strategy for antibacterial applications.