Mutagenic Activation of Glutathione Peroxidase-4: Approaches toward Rational Design of Allosteric Drugs

[Image: see text] Glutathione peroxidase 4 (GPX4) reduces lipid hydroperoxides in lipid membranes, effectively inhibiting iron-dependent cell death or ferroptosis. The upregulation of the enzyme by the mutations at residues D21 and D23 has been suggested to be associated with higher protein activity...

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Detalles Bibliográficos
Autores principales: Ma, Chunyue, Chung, Daniel J., Abramson, Dylan, Langley, David R., Thayer, Kelly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434792/
https://www.ncbi.nlm.nih.gov/pubmed/36061715
http://dx.doi.org/10.1021/acsomega.2c01289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434792/
https://www.ncbi.nlm.nih.gov/pubmed/36061715
http://dx.doi.org/10.1021/acsomega.2c01289

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